Informative gene selection for microarray classification via adaptive elastic net with conditional mutual information

DOI10.1016/J.APM.2019.01.044MaRDI QIDQ2310656zbMATH OpenOpenAlexWikidataFDO

Authors Yadi Wang, Yongjin Lu, Xinguang Yang

Publication date 6 April 2020

Published in Applied Mathematical Modelling (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1806.01466

zbMATH Keywords

elastic netconditional mutual informationcancer diagnosismicroarray data classification

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Genetics and epigenetics (92D10)

Abstract: Due to the advantage of achieving a better performance under weak regularization, elastic net has attracted wide attention in statistics, machine learning, bioinformatics, and other fields. In particular, a variation of the elastic net, adaptive elastic net (AEN), integrates the adaptive grouping effect. In this paper, we aim to develop a new algorithm: Adaptive Elastic Net with Conditional Mutual Information (AEN-CMI) that further improves AEN by incorporating conditional mutual information into the gene selection process. We apply this new algorithm to screen significant genes for two kinds of cancers: colon cancer and leukemia. Compared with other algorithms including Support Vector Machine, Classic Elastic Net and Adaptive Elastic Net, the proposed algorithm, AEN-CMI, obtains the best classification performance using the least number of genes.

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Cites work

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• scientific article; zbMATH DE number 845714 (Why is no real title available?)
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Cited in

(4)

• Multistage mutual information for informative gene selection
• Regression with adaptive Lasso and correlation based penalty
• Multinomial regression with elastic net penalty and its grouping effect in gene selection
• Classification of early-stage non-small cell lung cancer by weighting gene expression profiles with connectivity information

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Uses Software

• msgl

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