Stochastic simulation of pattern formation in growing tissue: a multilevel approach
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Publication:2325569
Abstract: We take up the challenge of designing realistic computational models of large interacting cell populations. The goal is essentially to bring Gillespie's celebrated stochastic methodology to the level of an interacting population of cells. Specifically, we are interested in how the gold standard of single cell computational modeling, here taken to be spatial stochastic reaction-diffusion models, may be efficiently coupled with a similar approach at the cell population level. Concretely, we target a recently proposed set of pathways for pattern formation involving Notch-Delta signaling mechanisms. These involve cell-to-cell communication as mediated both via direct membrane contact sites as well as via cellular protrusions. We explain how to simulate the process in growing tissue using a multilevel approach and we discuss implications for future development of the associated computational methods.
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Cited in
(16)- Numerical simulation of anisotropic tissue growth using a total Lagrangian formulation
- Invasiveness of a growth-migration system in a two-dimensional percolation cluster: a stochastic mathematical approach
- The emergence of complexity from a simple model for tissue growth
- Computational framework to capture the spatiotemporal density of cells with a cumulative environmental coupling
- Stochastic simulation of biochemical systems: in memory of Dan T. Gillespie's contributions
- On the role of physics in the growth and pattern formation of multi-cellular systems: what can we learn from individual-cell based models?
- Roughness and scaling in cellular patterns: Analysis of a simple model
- Exploring the effect of cell heterogeneity in wound healing using a 3D multicellular tissue growth model
- Particle simulations of morphogenesis
- On simulating the generation of mosaicism during mammalian cerebral cortical development
- scientific article; zbMATH DE number 764531 (Why is no real title available?)
- The Role of Random Structures in Tissue Formation: From a Viewpoint of Morphogenesis in Stochastic Systems
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- A framework for modelling and simulating networks of cells
- Coupling dynamics of 2D notch-delta signalling
- Modelling population-level Hes1 dynamics: insights from a multi-framework approach
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