Global weak solutions and asymptotic limits of a Cahn-Hilliard-Darcy system modelling tumour growth
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Publication:2335192
asymptotic analysischemotaxisweak solutionstumour growthphase field modelconvection-reaction-diffusion equationCahn-Hilliard-Darcy system
Asymptotic behavior of solutions to PDEs (35B40) Smoothness and regularity of solutions to PDEs (35B65) PDEs in connection with fluid mechanics (35Q35) Weak solutions to PDEs (35D30) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Flows in porous media; filtration; seepage (76S05) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)
Abstract: We study the existence of weak solutions to a Cahn--Hilliard--Darcy system coupled with a convection-reaction-diffusion equation through the fluxes, through the source terms and in Darcy's law. The system of equations arises from a mixture model for tumour growth accounting for transport mechanisms such as chemotaxis and active transport. We prove, via a Galerkin approximation, the existence of global weak solutions in two and three dimensions, along with new regularity results for the velocity field and for the pressure. Due to the coupling with the Darcy system, the time derivatives have lower regularity compared to systems without Darcy flow, but in the two dimensional case we employ a new regularity result for the velocity to obtain better integrability and temporal regularity for the time derivatives. Then, we deduce the global existence of weak solutions for two variants of the model; one where the velocity is zero and another where the chemotaxis and active transport mechanisms are absent.
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