Quantifying and estimating additive measures of interaction from case-control data

DOI10.15559/17-VMSTA77MaRDI QIDQ2360593zbMATH OpenFDO

Authors Lars Alfredsson, Anna Karin Hedström, Magnus Lekman, Ingrid Kockum, Tomas Olsson, Ola G. Hössjer

Publication date 4 July 2017

Published in Modern Stochastics. Theory and Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1707.00911

zbMATH Keywords

additive odds modelattributable proportioncase-control dataexpansion of odds ratiosinteraction of risk factorslogistic regression

Mathematics Subject Classification ID

Point estimation (62F10) Asymptotic properties of parametric estimators (62F12) Parametric tolerance and confidence regions (62F25) Generalized linear models (logistic models) (62J12) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: In this paper we develop a general framework for quantifying how binary risk factors jointly influence a binary outcome. Our key result is an additive expansion of odds ratios as a sum of marginal effects and interaction terms of varying order. These odds ratio expansions are used for estimating the excess odds ratio, attributable proportion and synergy index for a case-control dataset by means of maximum likelihood from a logistic regression model. The confidence intervals associated with these estimates of joint effects and interaction of risk factors rely on the delta method. Our methodology is illustrated with a large Nordic meta dataset for multiple sclerosis. It combines four studies, with a total of 6265 cases and 8401 controls. It has three risk factors (smoking and two genetic factors) and a number of other confounding variables.

Recommendations

• Additive and multiplicative models for the joint effect of two risk factors
• Measuring and estimating the interaction between exposures on a dichotomous outcome for observational studies
• Sample size and power calculations for additive interactions
• A general framework for and new normalization of attributable proportion
• A tutorial on interaction

Cites work

• A general framework for and new normalization of attributable proportion
• A survey of exact inference for contingency tables. With comments and a rejoinder by the author
• Attributable fractions: fundamental concepts and their visualization
• Better Bootstrap Confidence Intervals
• Empirical and counterfactual conditions for sufficient cause interactions
• scientific article; zbMATH DE number 47310 (Why is no real title available?)
• scientific article; zbMATH DE number 6107964 (Why is no real title available?)
• Logistic disease incidence models and case-control studies

Cited in

(4)

• A general framework for and new normalization of attributable proportion
• Sample size and power calculations for additive interactions
• The Additive Risk Model for Epidemiologic Interaction and the Analogy with Factorial Experiments
• Measuring and estimating the interaction between exposures on a dichotomous outcome for observational studies

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