Optimal design of dilution experiments under volume constraints

DOI10.1007/S13253-016-0259-0MaRDI QIDQ2363722zbMATH OpenOpenAlexFDO

Authors Maryam Zolghadr, Sergei Zuyev

Publication date 26 July 2017

Published in Journal of Agricultural, Biological and Environmental Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1212.3151

zbMATH Keywords

gradient methodsdesign measuredilution experimentFisher information criteriaone-stage designPoisson parameter inferencestem cell countingvariational analysis on measures

Mathematics Subject Classification ID

Bayesian inference (62F15) Optimal statistical designs (62K05) Applications of statistics to environmental and related topics (62P12) Parametric inference under constraints (62F30)

Abstract: The paper develops methods to construct a one-stage optimal design of dilution experiments under the total available volume constraint typical for bio-medical applications. We consider various design criteria based on the Fisher information both is Bayesian and non-Bayasian settings and show that the optimal design is typically one-atomic meaning that all the dilutions should be of the same size. The main tool is variational analysis of functions of a measure and the corresponding steepest descent type numerical methods. Our approach is generic in the sense that it allows for inclusion of additional constraints and cost components, like the cost of materials and of the experiment itself.

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Cited in

(4)

• Implementable Bayesian Designs for Limiting Dilution Assays
• Isovolumetric adaptations to space-filling design of experiments
• A two-stage experimental design for dilution assays
• Barycentric algorithm for computing D-optimal size- and cost-constrained designs of experiments

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