Cellular responding DNA damage: An improved modeling of P53 gene regulatory networks under ion radiation (IR)

DOI10.1016/J.AMC.2008.05.131MaRDI QIDQ2378737zbMATH OpenOpenAlexFDO

Authors Jinpeng Qi, Yizhen Shen, Shi-Huang Shao

Publication date 14 January 2009

Published in Applied Mathematics and Computation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.amc.2008.05.131

zbMATH Keywords

DNA damageIRmodelingoscillationsP53

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Medical applications (general) (92C50)

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Cited in

(9)

• A mathematical study of the robustness of G2/M regulatory network in response to DNA damage with parameters sensitivity
• Mathematical modeling of p53 pulses in G2 phase with DNA damage
• Change detection in the dynamics of an intracellular protein synthesis model using nonlinear Kalman filtering
• ATM and ATR activation through crosstalk between DNA damage response pathways
• A mathematical analysis of DNA damage induced G2 phase transition
• Single stranded-DNA detection: the role of Wip1 in ATR-dependent pathway
• Mathematical models and numerical simulations for the P53-Mdm2 network
• Regulation of p53 by SIRNA in radiation treated cells: simulation studies
• Construction of a Waddington-like landscape model that can guide clinical exploration of p53-dynamics-activating parameters in the face of divergent p53 dynamics

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