A mathematical model of low grade gliomas treated with temozolomide and its therapeutical implications

DOI10.1016/J.MBS.2017.02.003MaRDI QIDQ2407296zbMATH OpenOpenAlexWikidataFDO

Authors Yanyan Li

Publication date 29 September 2017

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1702.05307

zbMATH Keywords

chemotherapylogistic growthtemozolomidemathematical model of tumour responselow grade gliomas

Mathematics Subject Classification ID

Medical applications (general) (92C50) Boundary value problems with impulses for ordinary differential equations (34B37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: Low grade gliomas (LGGs) are infiltrative and incurable primary brain tumours with typically slow evolution. These tumours usually occur in young and otherwise healthy patients, bringing controversies in treatment planning since aggressive treatment may lead to undesirable side effects. Thus, for management decisions it would be valuable to obtain early estimates of LGG growth potential. Here we propose a simple mathematical model of LGG growth and its response to chemotherapy which allows the growth of LGGs to be described in real patients. The model predicts, and our clinical data confirms, that the speed of response to chemotherapy is related to tumour aggressiveness. Moreover, we provide a formula for the time to radiological progression, which can be possibly used as a measure of tumour aggressiveness. Finally, we suggest that the response to a few chemotherapy cycles upon diagnosis might be used to predict tumour growth and to guide therapeutical actions on the basis of the findings.

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Cited in

(15)

• Optimal control of cytotoxic and antiangiogenic therapies on prostate cancer growth
• A mathematical model of brain tumour response to radiotherapy and chemotherapy considering radiobiological aspects
• Some remarks on modelling of drug resistance for low grade gliomas
• Delay effects in the response of low-grade gliomas to radiotherapy: a mathematical model and its therapeutical implications
• Extreme protraction for low-grade gliomas: theoretical proof of concept of a novel therapeutical strategy
• Mathematical analysis and simulation study of a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects
• Mathematical analysis of a generalised model of chemotherapy for low grade gliomas
• A mathematical justification for metronomic chemotherapy in oncology
• Dynamics and analysis of a mathematical model of neuroblastoma treated with Celyvir
• Optimal control of therapies on a tumor growth model with brain lactate kinetics
• Modeling of drug resistance: Comparison of two hypotheses for slowly proliferating tumors on the example of low‐grade gliomas
• Mathematical and numerical analysis of low-grade gliomas model and the effects of chemotherapy
• Optimal control problems for differential equations applied to tumor growth: state of the art
• Travelling waves for low-grade glioma growth and response to a chemotherapy model
• Modelling and simulation of anisotropic growth in brain tumours through poroelasticity: a study of ventricular compression and therapeutic protocols

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