A mathematical model of low grade gliomas treated with temozolomide and its therapeutical implications
From MaRDI portal
Publication:2407296
DOI10.1016/J.MBS.2017.02.003zbMATH Open1377.92043arXiv1702.05307OpenAlexW2588804998WikidataQ38953990 ScholiaQ38953990MaRDI QIDQ2407296FDOQ2407296
Authors: Yanyan Li 
Publication date: 29 September 2017
Published in: Mathematical Biosciences (Search for Journal in Brave)
Abstract: Low grade gliomas (LGGs) are infiltrative and incurable primary brain tumours with typically slow evolution. These tumours usually occur in young and otherwise healthy patients, bringing controversies in treatment planning since aggressive treatment may lead to undesirable side effects. Thus, for management decisions it would be valuable to obtain early estimates of LGG growth potential. Here we propose a simple mathematical model of LGG growth and its response to chemotherapy which allows the growth of LGGs to be described in real patients. The model predicts, and our clinical data confirms, that the speed of response to chemotherapy is related to tumour aggressiveness. Moreover, we provide a formula for the time to radiological progression, which can be possibly used as a measure of tumour aggressiveness. Finally, we suggest that the response to a few chemotherapy cycles upon diagnosis might be used to predict tumour growth and to guide therapeutical actions on the basis of the findings.
Full work available at URL: https://arxiv.org/abs/1702.05307
Recommendations
- Delay effects in the response of low-grade gliomas to radiotherapy: a mathematical model and its therapeutical implications
- Mathematical and numerical analysis of low-grade gliomas model and the effects of chemotherapy
- Mathematical analysis of a generalised model of chemotherapy for low grade gliomas
- Extreme protraction for low-grade gliomas: theoretical proof of concept of a novel therapeutical strategy
- A mathematical model for brain tumor response to radiation therapy
Medical applications (general) (92C50) Boundary value problems with impulses for ordinary differential equations (34B37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)
Cites Work
- Mathematical biology. Vol. 1: An introduction.
- Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers
- Mathematical model of cancer growth controled by metronomic chemotherapies
- Phenomenological modeling of tumor diameter growth based on a mixed effects model
- Delay effects in the response of low-grade gliomas to radiotherapy: a mathematical model and its therapeutical implications
- Extreme protraction for low-grade gliomas: theoretical proof of concept of a novel therapeutical strategy
- Optimal radiation fractionation for low-grade gliomas: insights from a mathematical model
- A mathematical model of the treatment and survival of patients with high-grade brain tumours
- Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model
- A mathematical model of brain tumour response to radiotherapy and chemotherapy considering radiobiological aspects
Cited In (14)
- Mathematical analysis of a generalised model of chemotherapy for low grade gliomas
- Optimal control of cytotoxic and antiangiogenic therapies on prostate cancer growth
- Delay effects in the response of low-grade gliomas to radiotherapy: a mathematical model and its therapeutical implications
- Modeling of drug resistance: Comparison of two hypotheses for slowly proliferating tumors on the example of low‐grade gliomas
- A mathematical justification for metronomic chemotherapy in oncology
- Optimal control of therapies on a tumor growth model with brain lactate kinetics
- Extreme protraction for low-grade gliomas: theoretical proof of concept of a novel therapeutical strategy
- Dynamics and analysis of a mathematical model of neuroblastoma treated with Celyvir
- Some remarks on modelling of drug resistance for low grade gliomas
- Mathematical analysis and simulation study of a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects
- A mathematical model of brain tumour response to radiotherapy and chemotherapy considering radiobiological aspects
- Modelling and simulation of anisotropic growth in brain tumours through poroelasticity: a study of ventricular compression and therapeutic protocols
- Mathematical and numerical analysis of low-grade gliomas model and the effects of chemotherapy
- Optimal control problems for differential equations applied to tumor growth: state of the art
This page was built for publication: A mathematical model of low grade gliomas treated with temozolomide and its therapeutical implications
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2407296)
