Seven competing ways to recover the Michaelis-Menten equation reveal the alternative approaches to steady state modeling

DOI10.1007/S10910-013-0237-5MaRDI QIDQ2443867zbMATH OpenOpenAlexFDO

Authors Denis Michel, Philippe Ruelle

Publication date 8 April 2014

Published in Journal of Mathematical Chemistry (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1312.5468

zbMATH Keywords

enzyme kineticsrandom walksteady-statestochastic reaction chain

Mathematics Subject Classification ID

General biostatistics (92B15) Biochemistry, molecular biology (92C40) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: The Michaelis-Menten enzymatic reaction is sufficient to perceive many subtleties of network modeling, including the concentration and time scales separations, the formal equivalence between bulk phase and single-molecule approaches, or the relationships between single-cycle transient probabilities and steady state rates. Seven methods proposed by different authors and yielding the same famous Michaelis-Menten equation, are selected here to illustrate the kinetic and probabilistic use of rate constants and to review basic techniques for handling them. Finally, the general rate of an ordered multistep reaction, of which the Michaelis-Menten reaction is a particular case, is deduced from a Markovian approach.

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Cites work

• A probabilistic approach to compact steady-state kinetic equations for enzymic reactions
• Single-substrate enzyme kinetics: the quasi-steady-state approximation and beyond

Cited in

(7)

• A probabilistic approach to compact steady-state kinetic equations for enzymic reactions
• Metabolic rate constants: some computational aspects
• A new Michaelis-Menten equation valid everywhere multi-scale dynamics prevails
• A generalized Michaelis-Menten equation in protein synthesis: effects of mis-charged cognate tRNA and mis-reading of codon
• scientific article; zbMATH DE number 633874 (Why is no real title available?)
• A much better replacement of the Michaelis-Menten equation and its application
• Structural conditions on complex networks for the Michaelis-Menten input-output response

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