A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications

DOI10.1016/J.MBS.2014.01.001zbMATH Open1308.92050OpenAlexW2164480362WikidataQ45849334 ScholiaQ45849334MaRDI QIDQ2452893FDOQ2452893

Authors: Simon L. Goede, Melvin Khee-Shing Leow, Jan Smit, Johannes W. Dietrich 

Publication date: 5 June 2014

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2014.01.001

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zbMATH Keywords

parameterizationnegative exponentialclinical validationindividualized therapeutic targetlogarithmic-linear relationship

Mathematics Subject Classification ID

Medical applications (general) (92C50)

Cites Work

• A mathematical model of pituitary-thyroid interaction to provide an insight into the nature of the thyrotropin-thyroid hormone relationship
• General error analysis in the relationship between free thyroxine and thyrotropin and its clinical relevance
• A patient-specific model of the negative-feedback control of the hypothalamus-pituitary-thyroid (HPT) axis in autoimmune (Hashimoto's) thyroiditis
• Identification of the dynamics of thyroid hormone metabolism

Cited In (10)

• A mathematical model of parathyroid hormone response to acute changes in plasma ionized calcium concentration in humans
• A mathematical model of pituitary-thyroid interaction to provide an insight into the nature of the thyrotropin-thyroid hormone relationship
• High resolution free triiodothyronine-thyrotropin (FT3-TSH) responses to a single oral dose of liothyronine in humans: evidence of distinct inter-individual differences unraveled using an electrical network model
• A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in \textit{Xenopus laevis} larvae
• Hypothalamus-pituitary-thyroid feedback control: implications of mathematical modeling and consequences for thyrotropin (TSH) and free thyroxine (FT4) reference ranges
• A new mathematical model of hypothalamo-pituitary-thyroid axis
• A unified mathematical model of thyroid hormone regulation and implication for personalized treatment of thyroid disorders
• Model-based conceptualization of thyroid hormone equilibrium via set point and stability behavior
• General error analysis in the relationship between free thyroxine and thyrotropin and its clinical relevance
• A patient-specific model of the negative-feedback control of the hypothalamus-pituitary-thyroid (HPT) axis in autoimmune (Hashimoto's) thyroiditis

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