A time-varying shared frailty model with application to infectious diseases

DOI10.1214/13-AOAS693MaRDI QIDQ2453684zbMATH OpenFDO

Authors Doyo G. Enki, Angela Noufaily, C. Paddy Farrington

Publication date 10 June 2014

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1404.7339, https://projecteuclid.org/euclid.aoas/1396966293

zbMATH Keywords

current status datafrailtygammageneralized gammaheterogeneityinfectious diseaseshared frailty modeltime-varying frailty

Mathematics Subject Classification ID

Censored data models (62N01) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: We propose a new parametric time-varying shared frailty model to represent changes over time in population heterogeneity, for use with bivariate current status data. The model uses a power transformation of a time-invariant frailty $U$, and is particularly convenient when $U$ is a member of the generalized gamma family. This model avoids some shortcomings of a previously suggested time-varying frailty model, notably time-dependent support. We describe some key properties of the model, including its relative frailty variance function in different settings and how the model can be fitted to data. We describe several applications to shared frailty modeling of bivariate current status data on infectious diseases, in which the frailty represents age-dependent heterogeneity in contact rates or susceptibility to infection.

Recommendations

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Cites work

• Bivariate Survival Models Induced by Frailties
• Multivariate Survival Analysis Using Piecewise Gamma Frailty
• Survival and event history analysis. A process point of view
• The frailty model.

Cited in

(12)

• Semiparametric generalized exponential frailty model for clustered survival data
• Generalized inverse-Gaussian frailty models with application to TARGET neuroblastoma data
• Some results on the relative ordering of two frailty models
• A dynamic multistate model of robustness and frailty
• Bayesian framework for parametric bivariate accelerated lifetime modeling and its application to hospital acquired infections
• A note on the prediction of frailties with misspecified shared frailty models
• On comparisons of population and subpopulations in frailty models
• Promotion time models with time-changing exposure and heterogeneity: application to infectious diseases
• Shared frailty model for recurrent event data with multiple causes
• The relative frailty variance and shared frailty models
• Exploring shared frailty models for cluster-specific risk estimation: a study on diabetes patients with a history of acute coronary syndrome
• Bias reduction methods in the hierarchical likelihood approach for shared frailty model of clustered failure time data

Describes a project that uses

Uses Software

• invGauss
• R

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