Accounting for spatial correlation in the scan statistic

DOI10.1214/07-AOAS129zbMATH Open1126.62107arXiv0712.1458WikidataQ60521660 ScholiaQ60521660MaRDI QIDQ2466478FDOQ2466478

Authors: Ji Meng Loh, Zhengyuan Zhu 

Publication date: 15 January 2008

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: The spatial scan statistic is widely used in epidemiology and medical studies as a tool to identify hotspots of diseases. The classical spatial scan statistic assumes the number of disease cases in different locations have independent Poisson distributions, while in practice the data may exhibit overdispersion and spatial correlation. In this work, we examine the behavior of the spatial scan statistic when overdispersion and spatial correlation are present, and propose a modified spatial scan statistic to account for that. Some theoretical results are provided to demonstrate that ignoring the overdispersion and spatial correlation leads to an increased rate of false positives, which is verified through a simulation study. Simulation studies also show that our modified procedure can substantially reduce the rate of false alarms. Two data examples involving brain cancer cases in New Mexico and chickenpox incidence data in France are used to illustrate the practical relevance of the modified procedure.

Full work available at URL: https://arxiv.org/abs/0712.1458

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zbMATH Keywords

overdispersionmultiple comparisonsspatial scan statisticspatial generalized linear mixed model

Mathematics Subject Classification ID

Inference from spatial processes (62M30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Paired and multiple comparisons; multiple testing (62J15)

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Cited In (14)

• Bayesian scanning of spatial disease rates with integrated nested Laplace approximation (INLA)
• Spatial scan statistics based on empirical likelihood
• Identifying high-density regions of pests within an orchard
• Family of power divergence spatial scan statistics
• Wald-based spatial scan statistics for cluster detection
• Spatial scan statistics for models with overdispersion and inflated zeros
• Generalized scan statistics for disease surveillance
• Spatial scan statistics in loglinear models
• Cluster Detection Based on Spatial Associations and Iterated Residuals in Generalized Linear Mixed Models
• Spatial cluster detection of regression coefficients in a mixed-effects model
• A shared-frailty spatial scan statistic model for time-to-event data
• Scan statistics for detecting high-variance clusters
• On the effective geographic sample size
• A Wilcoxon-Mann-Whitney spatial scan statistic for functional data

Uses Software

• geoRglm
• SaTScan

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