A schematic age-structured compartment model of the impact of antiretroviral therapy on HIV incidence and prevalence

DOI10.1016/J.MATCOM.2006.01.004zbMATH Open1087.92040DBLPjournals/mcs/LopezCBM06arXivq-bio/0501009OpenAlexW2149237788WikidataQ56764243 ScholiaQ56764243MaRDI QIDQ2490481FDOQ2490481

Authors: M. N. Burattini, Eduardo Massad, L. F. Lopez, F. A. B. Coutinho 

Publication date: 16 May 2006

Published in: Mathematics and Computers in Simulation (Search for Journal in Brave)

Abstract: A simple deterministic model is proposed to represent the basic aspects concerning the effects of different antiretroviral treatment schedules on HIV incidence and prevalence of affected populations. The model mimics current treatment guidelines applied in Brazil. However, the model does not intend to fit the data with any acceptable degree of accuracy since uncertainties on the values of the parameters and on the precise effect of the treatment put some limits on the practical implications of our model from which only orders of magnitude and some qualitative effects can be deduced. So, this paper intends to provide a conceptual and mechanistic understanding of the possible long term effects of treatment on the dynamics of HIV transmission. According to the model, the effect of the treatment depends on the level of sexual activity of the subpopulations considered, being more pronounced on the subpopulations with the highest sexual activity levels. Also, inefficient treatment can be prejudicial depending on the level of sexual activity and on the capacity to provide adequate treatment coverages to the population affected.

Full work available at URL: https://arxiv.org/abs/q-bio/0501009

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zbMATH Keywords

HAARTdeterministic modelBrazil

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60)

Cites Work

• Modelling heterogeneities in individual frailties in epidemic models.
• The intrinsic rate of increase of HIV/AIDS: Epidemiological and evolutionary implications
• Modelling the natural history of HIV infection in individuals and its epidemiological implications
• Title not available (Why is that?)
• On the uniqueness of the positive solution of an integral equation which appears in epidemiological models

Cited In (6)

• A fuzzy Reed-Frost model for epidemic spreading
• Modelling treatment effects in the HIV/AIDS epidemic
• Erratum to ``A schematic age-structured compartment model of the impact of antiretroviral therapy on HIV incidence and prevalence
• Incubation periods under various anti-retroviral therapies in homogeneous mixing and age-structured dynamical models: a theoretical approach
• Dynamical analysis of a multi-strain model of HIV in the presence of anti-retroviral drugs
• An age-structured model for the potential impact of generalized access to antiretrovirals on the South African HIV epidemic

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