On the efficiency of adaptive designs for flexible interim decisions in clinical trials

DOI10.1016/j.jspi.2005.08.014zbMath1089.62127WikidataQ57305803 ScholiaQ57305803MaRDI QIDQ2492935

Peter Bauer, Martin Posch, Werner Brannath

Publication date: 9 June 2006

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2005.08.014

zbMATH Keywords

likelihood ratio test; adaptive design; inefficiency; \(\alpha\)-spending; group-sequential test

Mathematics Subject Classification ID

62P10: Applications of statistics to biology and medical sciences; meta analysis

62L05: Sequential statistical design

62L10: Sequential statistical analysis

Related Items

Sample Size Re-Estimation Based on Two-Stage Analysis of Variance: Interim Analysis of Clinical Trials, Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

Cites Work

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• Optimal Conditional Error Functions for the Control of Conditional Power
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• On the inefficiency of the adaptive design for monitoring clinical trials
• A Unified Theory of Two-Stage Adaptive Designs
• Evaluation of Experiments with Adaptive Interim Analyses