Attentional modulation of firing rate and synchrony in a model cortical network

DOI10.1007/S10827-006-6358-0MaRDI QIDQ2500155zbMATH OpenOpenAlexWikidataFDO

Authors Calin Buia, P. H. E. Tiesinga

Publication date 23 August 2006

Published in Journal of Computational Neuroscience (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0512021

zbMATH Keywords

SynchronizationAttentionDelay modulationSynchrony modulation

Mathematics Subject Classification ID

Neural biology (92C20)

Abstract: When attention is directed into the receptive field of a V4 neuron, its contrast response curve is shifted to lower contrast values (Reynolds et al, 2000, Neuron 26:703). Attention also increases the coherence between neurons responding to the same stimulus (Fries et al, 2001, Science 291:1560). We studied how the firing rate and synchrony of a densely interconnected cortical network varied with contrast and how they were modulated by attention. We found that an increased driving current to the excitatory neurons increased the overall firing rate of the network, whereas variation of the driving current to inhibitory neurons modulated the synchrony of the network. We explain the synchrony modulation in terms of a locking phenomenon during which the ratio of excitatory to inhibitory firing rates is approximately constant for a range of driving current values. We explored the hypothesis that contrast is represented primarily as a drive to the excitatory neurons, whereas attention corresponds to a reduction in driving current to the inhibitory neurons. Using this hypothesis, the model reproduces the following experimental observations: (1) the firing rate of the excitatory neurons increases with contrast; (2) for high contrast stimuli, the firing rate saturates and the network synchronizes; (3) attention shifts the contrast response curve to lower contrast values; (4) attention leads to stronger synchronization that starts at a lower value of the contrast compared with the attend-away condition. In addition, it predicts that attention increases the delay between the inhibitory and excitatory synchronous volleys produced by the network, allowing the stimulus to recruit more downstream neurons.

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Cites work

• scientific article; zbMATH DE number 1505847 (Why is no real title available?)
• Asynchronous States and the Emergence of Synchrony in Large Networks of Interacting Excitatory and Inhibitory Neurons
• Effects of Noisy Drive on Rhythms in Networks of Excitatory and Inhibitory Neurons
• Rapid Temporal Modulation of Synchrony by Competition in Cortical Interneuron Networks
• Synchronization and oscillatory dynamics in heterogeneous, mutually inhibited neurons
• Synchronization in Networks of Excitatory and Inhibitory Neurons with Sparse, Random Connectivity

Cited in

(16)

• Feature-based attention by lateral spike synchronization
• Dynamic Gain Changes During Attentional Modulation
• Selective interareal synchronization through gamma frequency differences and slower-rhythm gamma phase reset
• RATE AND GAMMA MODULATION IN ATTENTIONAL TASKS
• Selective attention through phase relationship of excitatory and inhibitory input synchrony in a model cortical neuron
• The micro-structure of attention
• Stimulus Competition by Inhibitory Interference
• Dynamical changes in neurons during seizures determine tonic to clonic shift
• Flexible frequency switching in adult mouse visual cortex is mediated by competition between parvalbumin and somatostatin expressing interneurons
• Selective Population Rate Coding: A Possible Computational Role of Gamma Oscillations in Selective Attention
• Computational model of excitatory/inhibitory ratio imbalance role in attention deficit disorders
• Attentional bias through oscillatory coherence between excitatory activity and inhibitory minima
• Rapid Temporal Modulation of Synchrony by Competition in Cortical Interneuron Networks
• Biased competition through variations in amplitude of $\gamma$-oscillations
• Finding the event structure of neuronal spike trains
• Attention modulation of neural tuning through peak and base rate

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