Multi-stability in monotone input/output systems
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Publication:2503574
DOI10.1016/J.SYSCONLE.2003.08.003zbMATH Open1157.93509arXivq-bio/0309002OpenAlexW2063268016MaRDI QIDQ2503574FDOQ2503574
Eduardo D. Sontag, David Angeli
Publication date: 21 September 2006
Published in: Systems \& Control Letters (Search for Journal in Brave)
Abstract: This paper studies the emergence of multi-stability and hysteresis in those systems that arise, under positive feedback, starting from monotone systems with well-defined steady-state responses. Such feedback configurations appear routinely in several fields of application, and especially in biology. Characterizations of global stability behavior are stated in terms of easily checkable graphical conditions. An example of a signaling cascade under positive feedback is presented.
Full work available at URL: https://arxiv.org/abs/q-bio/0309002
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Cited In (40)
- Monotone systems under positive feedback: multistability and a reduction theorem
- Molecular systems biology and control
- On a Smale theorem and nonhomogeneous equilibria in cooperative systems
- Stability and robust position control of hysteretic systems
- Self-sustaining positive feedback loops in discrete and continuous systems
- A control approach for monotone systems with multi-valued characteristics: application to an ebola virus model
- Asymptotic stability criterion for nonlinear monotonic systems and its applications (review)
- Oscillations in multi-stable monotone systems with slowly varying feedback
- Structural analysis in biology: a control-theoretic approach
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