Approximate marginalization of absorption and scattering in fluorescence diffuse optical tomography

DOI10.3934/IPI.2016.10.227zbMATH Open1332.74034arXiv1501.00384OpenAlexW2962972877MaRDI QIDQ254804FDOQ254804

Authors: Meghdoot Mozumder, Tanja Tarvainen, Jari P. Kaipio, Cosimo D'Andrea, Ville Kolehmainen, Simon Arridge 

Publication date: 16 March 2016

Published in: Inverse Problems and Imaging (Search for Journal in Brave)

Abstract: In fluorescence diffuse optical tomography (fDOT), the reconstruction of the fluorophore concentration inside the target body is usually carried out using a normalized Born approximation model where the measured fluorescent emission data is scaled by measured excitation data. One of the benefits of the model is that it can tolerate inaccuracy in the absorption and scattering distributions that are used in the construction of the forward model to some extent. In this paper, we employ the recently proposed Bayesian approximation error approach to fDOT for compensating for the modeling errors caused by the inaccurately known optical properties of the target in combination with the normalized Born approximation model. The approach is evaluated using a simulated test case with different amount of error in the optical properties. The results show that the Bayesian approximation error approach improves the tolerance of fDOT imaging against modeling errors caused by inaccurately known absorption and scattering of the target.

Full work available at URL: https://arxiv.org/abs/1501.00384

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zbMATH Keywords

Bayesian methodsinverse problemsfluorescence diffuse optical tomographyimage reconstruction techniquestomography

Mathematics Subject Classification ID

Biomedical imaging and signal processing (92C55) Numerical methods for inverse problems for integral equations (65R32) Inverse problems for waves in solid mechanics (74J25)

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Cited In (8)

• Optimal design of large-scale nonlinear Bayesian inverse problems under model uncertainty
• Fluorescence molecular imaging based on the adjoint radiative transport equation
• Approximate peak time and its application to time-domain fluorescence diffuse optical tomography
• Estimation of the Robin coefficient field in a Poisson problem with uncertain conductivity field
• Approximation errors and model reduction with an application in optical diffusion tomography
• An approximation error approach for compensating for modelling errors between the radiative transfer equation and the diffusion approximation in diffuse optical tomography
• On fluorophore imaging by diffusion equation model: decompositions and optimizations
• Noise filtration in fluorescence-enhanced optical tomography: breast phantom studies

Uses Software

• GMRFLib

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