On the convergence of the generalized linear least squares algorithm
algorithmclinical positron emission tomographydynamic systemGauss-Newton algorithmsgeneralized linear least squaresinverse problemiterative methodsnumerical experimentsparameter estimation
Numerical solutions to overdetermined systems, pseudoinverses (65F20) Numerical optimization and variational techniques (65K10) Biomedical imaging and signal processing (92C55) System identification (93B30) Control/observation systems governed by ordinary differential equations (93C15) Control/observation systems in abstract spaces (93C25)
The authors present theoretical considerations concerning the generalized linear least squares (GLLS) algorithm, first introduced by \textit{D. Feng} and \textit{D. Ho} [Parametric imaging algorithms for multicompartmental models dynamic studies with positron emission tomography, in K. Uemura, N. A. Lassen, T. Jones, and I. Kanno (eds.), Quantification of Brain Function:Tracer Kinetics and Image Analysis in Brain PET, Elsevier Science Publishers, Amsterdam,The Netherlands 127--137 (1993)]. They consider the inverse problem of parameter estimate of a linear continuous dynamic system by introducing in GLLS both Gauss-Newton and alternating Gauss-Newton algorithms for solving it. Numerical experiments in the field of clinical positron emission tomography are also presented.
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