Uniqueness of weak solutions to a prion equation with polymer joining

DOI10.1515/ANLY-2016-0034MaRDI QIDQ2628098zbMATH OpenOpenAlexFDO

Authors Elena Leis, Christoph Walker

Publication date 12 June 2017

Published in Analysis (München) (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1703.08335

zbMATH Keywords

polymer splittingprion polymerizationprionsunbounded reaction rates

Mathematics Subject Classification ID

Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) Weak solutions to PDEs (35D30) Initial value problems for nonlinear first-order PDEs (35F25) Integro-partial differential equations (35R09) Integro-partial differential equations (45K05) General biology and biomathematics (92B05)

Abstract: We consider a model for prion proliferation that includes prion polymerization, polymer splitting, and polymer joining. The model consists of an ordinary differential equation for the prion monomers and a hyperbolic nonlinear differential equation with integral terms for the prion polymers and was shown to possess global weak solutions for unbounded reaction rates [11]. Here we prove the uniqueness of weak solutions.

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Cites work

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Cited in

(5)

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• Well-posedness for a model of prion proliferation dynamics
• Prion proliferation with unbounded polymerization rates
• The shape of the polymerization rate in the prion equation
• Existence of global classical and weak solutions to a prion equation with polymer joining

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