A novel neighborhood-based computational model for potential miRNA-disease association prediction
Summary: In recent years, more and more studies have shown that miRNAs can affect a variety of biological processes. It is important for disease prevention, treatment, diagnosis, and prognosis to study the relationships between human diseases and miRNAs. However, traditional experimental methods are time-consuming and labour-intensive. Hence, in this paper, a novel neighborhood-based computational model called NBMDA is proposed for predicting potential miRNA-disease associations. Due to the fact that known miRNA-disease associations are very rare and many diseases (or miRNAs) are associated with only one or a few miRNAs (or diseases), in NBMDA, the \(K\)-nearest neighbor (KNN) method is utilized as a recommendation algorithm based on known miRNA-disease associations, miRNA functional similarity, disease semantic similarity, and Gaussian interaction profile kernel similarity for miRNAs and diseases to improve its prediction accuracy. And simulation results demonstrate that NBMDA can effectively infer miRNA-disease associations with higher accuracy compared with previous state-of-the-art methods. Moreover, independent case studies of esophageal neoplasms, breast neoplasms and colon neoplasms are further implemented, and as a result, there are 47, 48, and 48 out of the top 50 predicted miRNAs having been successfully confirmed by the previously published literatures, which also indicates that NBMDA can be utilized as a powerful tool to study the relationships between miRNAs and diseases.
- A new computational method based on heterogeneous network for predicting microRNA-disease associations
- miRNA-disease association prediction with collaborative matrix factorization
- A novel approach for predicting disease-lncRNA associations based on the distance correlation set and information of the miRNAs
- Maximal entropy random walk on heterogenous network for miRNA-disease association prediction
- A novel method for predicting disease-associated lncRNA-mIRNA pairs based on the higher-order orthogonal iteration
- miRNA-disease association prediction with collaborative matrix factorization
- A novel approach for predicting disease-lncRNA associations based on the distance correlation set and information of the miRNAs
- A novel model for predicting associations between diseases and lncRNA-miRNA pairs based on a newly constructed bipartite network
- A novel method for predicting disease-associated lncRNA-mIRNA pairs based on the higher-order orthogonal iteration
- Detecting composite functional module in miRNA regulation and mRNA interaction network
- A new computational method based on heterogeneous network for predicting microRNA-disease associations
- Identify potential circRNA-disease associations through a multi-objective evolutionary algorithm
- Maximal entropy random walk on heterogenous network for miRNA-disease association prediction
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