Modeling the synergistic properties of drugs in hormonal treatment for prostate cancer

DOI10.1016/J.JTBI.2020.110570MaRDI QIDQ2659871zbMATH OpenOpenAlexFDO

Authors Trevor Reckell, Kyle Nguyen, Tin Phan, Sharon M. Crook, Eric J. Kostelich, Yang Kuang

Publication date 29 March 2021

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2020.110570

zbMATH Keywords

adaptive therapyandrogen dynamicsdrug effectshormonal therapyintermittent androgen deprivation therapyoptimal treatment schedulepharmacokineticsprostate cancer modeling

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

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Cites work

• A mathematical model of prostate tumor growth and androgen-independent relapse
• Development of a mathematical model that predicts the outcome of hormone therapy for prostate cancer
• Global dynamics of a model of joint hormone treatment with dendritic cell vaccine for prostate cancer
• Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates
• scientific article; zbMATH DE number 1529823 (Why is no real title available?)
• Making best use of model evaluations to compute sensitivity indices
• Modeling the effect of immunotherapies on human castration-resistant prostate cancer
• Optimal control of multiplicative control systems arising from cancer therapy
• Optimal control to develop therapeutic strategies for metastatic castrate resistant prostate cancer
• Optimal design of personalized prostate cancer therapy using infinitesimal perturbation analysis
• Parameter selection and verification techniques based on global sensitivity analysis illustrated for an HIV model
• Practically scheduling hormone therapy for prostate cancer using a mathematical model
• Predictability and identifiability assessment of models for prostate cancer under androgen suppression therapy
• Variance based sensitivity analysis of model output. Design and estimator for the total sensitivity index

Cited in

(5)

• The dynamics of relapses during treatment switch in relapsing-remitting multiple sclerosis
• A hybrid spatiotemporal model of PCa dynamics and insights into optimal therapeutic strategies
• Modeling prostate cancer response to continuous versus intermittent androgen ablation therapy
• Does Finasteride Affect the Severity of Prostate Cancer? A Causal Sensitivity Analysis
• An integrative model of prostate cancer interaction with the bone microenvironment

Describes a project that uses

Uses Software

• Matlab
• DrugBank

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