A tale of two receptors

DOI10.1016/J.JTBI.2021.110629MaRDI QIDQ2659917zbMATH OpenOpenAlexFDO

Authors Ielyaas Cloete, Juliana C. Corrêa-Velloso, Paula J. Bartlett, Andrew P. Thomas, James Sneyd, Vivien Kirk

Publication date 29 March 2021

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2021.110629

zbMATH Keywords

Ca\(^{2+}\) oscillationshepatocytesIP\(_3\) receptorP2Y receptorphospholipase Cprotein kinase C

Mathematics Subject Classification ID

Cell biology (92C37) Biochemistry, molecular biology (92C40)

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Cites work

• Dual mechanisms of Ca\(^{2+}\) oscillations in hepatocytes
• Models of calcium signalling
• Spatio-temporal modelling explains the effect of reduced plasma membrane Ca\(^{2+}\) efflux on intracellular Ca\(^{2+}\) oscillations in hepatocytes

Cited in

(8)

• Spatio-temporal modelling explains the effect of reduced plasma membrane Ca\(^{2+}\) efflux on intracellular Ca\(^{2+}\) oscillations in hepatocytes
• Metabotropic receptor activation, desensitization and sequestration. I: Modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation
• Dual mechanisms of Ca\(^{2+}\) oscillations in hepatocytes
• Computational biology analysis of platelet signaling reveals roles of feedbacks through phospholipase C and inositol 1,4,5-trisphosphate 3-kinase in controlling amplitude and duration of calcium oscillations
• Cellular calcium oscillations: from bifurcation analysis to experiment
• Emergence of broad cytosolic \(\mathrm{Ca}^{2+}\) oscillations in the absence of CRAC channels: a model for CRAC-mediated negative feedback on PLC and \(\mathrm{Ca}^{2+}\) oscillations through PKC
• A model for the coexistence of competing mechanisms for \(\text{Ca}^{2+}\) oscillations in T-lymphocytes
• Understanding broad-spike oscillations in a model of intracellular calcium dynamics

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