Theoretical evidence of osteoblast self-inhibition after activation of the genetic regulatory network controlling mineralization

DOI10.1016/J.JTBI.2022.111005MaRDI QIDQ2670156zbMATH OpenOpenAlexFDO

Authors Abdennasser Chekroun, Laurent Pujo-Menjouet, Steve Falcoz, Kamyine Tsuen, Kevin Yueh-Hsun Yang, Jean-Philippe Berteau

Publication date 10 March 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111005

zbMATH Keywords

bonegenetic networkHill functionsnonlinear differential equations

Mathematics Subject Classification ID

Physiology (general) (92C30) Systems biology, networks (92C42) Genetics and epigenetics (92D10)

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Cites work

• A mechano-regulatory bone-healing model incorporating cell-phenotype specific activity
• Osteocytes as a record of bone formation dynamics: a mathematical model of osteocyte generation in bone matrix

Cited in

(4)

• Mineralization-driven bone tissue evolution follows from fluid-to-solid phase transformations in closed thermodynamic systems
• Understanding the fundamental molecular mechanism of osteogenic differentiation from mesenchymal stem cells
• Modeling cell decisions in bone formation
• Stiffness-sensitive gene regulation in human mesenchymal stem cells: modelling mechanotransduction to predict mineralization and bone protein expression

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