Designing experimental conditions to use the Lotka-Volterra model to infer tumor cell line interaction types
From MaRDI portal
Publication:2678765
Abstract: The Lotka-Volterra model is widely used to model interactions between two species. Here, we generate synthetic data mimicking competitive, mutualistic and antagonistic interactions between two tumor cell lines, and then use the Lotka-Volterra model to infer the interaction type. Structural identifiability of the Lotka-Volterra model is confirmed, and practical identifiability is assessed for three experimental designs: (a) use of a single data set, with a mixture of both cell lines observed over time, (b) a sequential design where growth rates and carrying capacities are estimated using data from experiments in which each cell line is grown in isolation, and then interaction parameters are estimated from an experiment involving a mixture of both cell lines, and (c) a parallel experimental design where all model parameters are fitted to data from two mixtures simultaneously. In addition to assessing each design for practical identifiability, we investigate how the predictive power of the model-i.e., its ability to fit data for initial ratios other than those to which it was calibrated-is affected by the choice of experimental design. The parallel calibration procedure is found to be optimal and is further tested on in silico data generated from a spatially-resolved cellular automaton model, which accounts for oxygen consumption and allows for variation in the intensity level of the interaction between the two cell lines. We use this study to highlight the care that must be taken when interpreting parameter estimates for the spatially-averaged Lotka-Volterra model when it is calibrated against data produced by the spatially-resolved cellular automaton model, since baseline competition for space and resources in the CA model may contribute to a discrepancy between the type of interaction used to generate the CA data and the type of interaction inferred by the LV model.
Recommendations
- Testing interaction in some predator-prey populations
- Harnessing uncertainty to approximate mechanistic models of interspecific interactions
- Rigorous mapping of data to qualitative properties of parameter values and dynamics: a case study on a two-variable Lotka-Volterra system
- Analysis of a spatial Lotka-Volterra model with a finite range predator-prey interaction
Cites work
- A framework for performing data-driven modeling of tumor growth with radiotherapy treatment
- Global identifiability of the parameters of nonlinear systems with specified inputs: A comparison of methods
- Joining forces of Bayesian and frequentist methodology: a study for inference in the presence of non-identifiability
- Lotka-Volterra model parameter estimation using experiential data
- Mathematical models of tumor-immune system dynamics. Proceedings of the international workshop, Sydney, Australia, January 7--10, 2013
- Modeling the connection between primary and metastatic tumors
- Nonlinear modelling of cancer: bridging the gap between cells and tumours
- Observability and structural identifiability of nonlinear biological systems
- Optimal control to develop therapeutic strategies for metastatic castrate resistant prostate cancer
- Parameter identifiability and model selection for sigmoid population growth models
- System identifiability based on the power series expansion of the solution
- The impact of competition between cancer cells and healthy cells on optimal drug delivery
- Uncertainty quantification. Theory, implementation, and applications
Cited in
(5)- Machine learning approach for higher-order interactions detection to ecological communities management
- Negligible long-term impact of nonlinear growth dynamics on heterogeneity in models of cancer cell populations
- On the dynamics of antigen receptors on the B-cell membrane through a two-dimensional stochastic process
- Inferring birth versus death dynamics for ecological interactions in stochastic heterogeneous populations
- A normalized time-fractional Lotka-Volterra model
This page was built for publication: Designing experimental conditions to use the Lotka-Volterra model to infer tumor cell line interaction types
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2678765)
