Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

DOI10.1007/978-1-4939-2782-1_1zbMath1338.92047arXiv1412.0780OpenAlexW1674806584MaRDI QIDQ2799978

Jana L. Gevertz, Katarzyna A. Rejniak, Kerri-Ann Norton, Alexandria Volkening, Zahra Aminzare, Judith Pérez-Velázquez

Publication date: 14 April 2016

Published in: The IMA Volumes in Mathematics and its Applications (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1412.0780

zbMATH Keywords

hybrid modelindividual cell-based modeltumor therapytumor environment

Mathematics Subject Classification ID

Medical applications (general) (92C50)

Related Items (4)

A biophysical model of cell evolution after cytotoxic treatments: damage, repair and cell response ⋮ Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases ⋮ Comparison of drug inhibitory effects \((\mathrm{IC}_{50})\) in monolayer and spheroid cultures ⋮ On minimising tumoural growth under treatment resistance

Cites Work

• Stochastic modeling of cellular colonies with quiescence: an application to drug resistance in cancer
• A mathematical model to study the effects of drug resistance and vasculature on the response of solid tumors to chemotherapy
• The impact of cell density and mutations in a model of multidrug resistance in solid tumors
• Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors
• Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies

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