Homogenization of oxygen transport in biological tissues

DOI10.1080/00036811.2015.1049600zbMATH Open1342.35030arXiv1406.6722OpenAlexW1568981804MaRDI QIDQ2805624FDOQ2805624

Mariya Ptashnyk, Anastasios Matzavinos

Publication date: 12 May 2016

Published in: Applicable Analysis (Search for Journal in Brave)

Abstract: In this paper, we extend previous work on the mathematical modeling of oxygen transport in biological tissues (Matzavinos et al., 2009). Specifically, we include in the modeling process the arterial and venous microstructure within the tissue by means of homogenization techniques. We focus on the two-layer tissue architecture investigated in (Matzavinos et al., 2009) in the context of abdominal tissue flaps that are commonly used for reconstructive surgery. We apply two-scale convergence methods and unfolding operator techniques to homogenize the developed microscopic model, which involves different unit-cell geometries in the two distinct tissue layers (skin layer and fat tissue) to account for different arterial branching patterns.

Full work available at URL: https://arxiv.org/abs/1406.6722

zbMATH Keywords

periodic homogenizationtwo-scale convergencethin domainstissue engineeringunfolding methodreconstructive surgeryarterial branching patternDIEP tissue flap

Mathematics Subject Classification ID

Homogenization in context of PDEs; PDEs in media with periodic structure (35B27) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Homogenization and oscillations in dynamical problems of solid mechanics (74Q10) Effective constitutive equations in solid mechanics (74Q15)

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Cited In (9)

• Title not available (Why is that?)
• Singular Limit for Reactive Diffusive Transport Through an Array of Thin Channels in case of Critical Diffusivity
• The mechanics of lung tissue under high-frequency ventilation
• Some factors affecting pulmonary oxygen transport
• Diffusion and reaction controlled dissolution of oxygen microbubbles in blood
• On the analysis of oxygen diffusion and reaction in biological systems
• Homogenization theory of ion transportation in multicellular tissue
• Coarse-graining and hybrid methods for efficient simulation of stochastic multi-scale models of tumour growth
• A MULTIPHASE MULTISCALE MODEL FOR NUTRIENT LIMITED TISSUE GROWTH

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