Homogenization of oxygen transport in biological tissues

DOI10.1080/00036811.2015.1049600MaRDI QIDQ2805624zbMATH OpenOpenAlexFDO

Authors Anastasios Matzavinos, Mariya Ptashnyk

Publication date 12 May 2016

Published in Applicable Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1406.6722

zbMATH Keywords

periodic homogenizationtwo-scale convergencethin domainstissue engineeringunfolding methodreconstructive surgeryarterial branching patternDIEP tissue flap

Mathematics Subject Classification ID

Homogenization in context of PDEs; PDEs in media with periodic structure (35B27) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Homogenization and oscillations in dynamical problems of solid mechanics (74Q10) Effective constitutive equations in solid mechanics (74Q15)

Abstract: In this paper, we extend previous work on the mathematical modeling of oxygen transport in biological tissues (Matzavinos et al., 2009). Specifically, we include in the modeling process the arterial and venous microstructure within the tissue by means of homogenization techniques. We focus on the two-layer tissue architecture investigated in (Matzavinos et al., 2009) in the context of abdominal tissue flaps that are commonly used for reconstructive surgery. We apply two-scale convergence methods and unfolding operator techniques to homogenize the developed microscopic model, which involves different unit-cell geometries in the two distinct tissue layers (skin layer and fat tissue) to account for different arterial branching patterns.

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Cited in

(11)

• scientific article; zbMATH DE number 5205462 (Why is no real title available?)
• Mathematical homogenization in the modelling of digestion in the small intestine
• The mechanics of lung tissue under high-frequency ventilation
• Some factors affecting pulmonary oxygen transport
• A multiphase multiscale model for nutrient limited tissue growth
• Diffusion and reaction controlled dissolution of oxygen microbubbles in blood
• On the analysis of oxygen diffusion and reaction in biological systems
• Homogenization of the diffusion equation with a singular potential for a model of a biological cell network
• Coarse-graining and hybrid methods for efficient simulation of stochastic multi-scale models of tumour growth
• Homogenization theory of ion transportation in multicellular tissue
• Singular limit for reactive diffusive transport through an array of thin channels in case of critical diffusivity

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