Bayesian model-averaged benchmark dose analysis via reparameterized quantal-response models
From MaRDI portal
Publication:2809552
Abstract: An important objective in biomedical risk assessment is estimation of minimum exposure levels that induce a pre-specified adverse response in a target population. The exposure/dose points in such settings are known as Benchmark Doses (BMDs). Recently, parametric Bayesian estimation for finding BMDs has become popular. A large variety of candidate dose-response models is available for applying these methods, however, leading to questions of model adequacy and uncertainty. Here we enhance the Bayesian estimation technique for BMD analysis by applying Bayesian model averaging to produce point estimates and (lower) credible bounds. We include reparameterizations of traditional dose-response models that allow for more-focused use of elicited prior information when building the Bayesian hierarchy. Performance of the method is evaluated via a short simulation study. An example from carcinogenicity testing illustrates the calculations.
Recommendations
- Bayesian Model Averaging With Applications to Benchmark Dose Estimation for Arsenic in Drinking Water
- Nonparametric benchmark dose estimation with continuous dose-response data
- Benchmark dose profiles for joint-action continuous data in quantitative risk assessment
- Bayesian Analysis for Linearized Multi-Stage Models in Quantal Bioassay
- Benchmark dose profiles for joint-action quantal data in quantitative risk assessment
Cites work
- scientific article; zbMATH DE number 2063756 (Why is no real title available?)
- scientific article; zbMATH DE number 947416 (Why is no real title available?)
- A New Perspective on Priors for Generalized Linear Models
- Bayesian Model Averaging With Applications to Benchmark Dose Estimation for Arsenic in Drinking Water
- Bayesian model averaging: A tutorial. (with comments and a rejoinder).
- Contemporary Bayesian Econometrics and Statistics
- On the half-Cauchy prior for a global scale parameter
- Prior distributions for variance parameters in hierarchical models (Comment on article by Browne and Draper)
Cited in
(11)- Benchmark dose profiles for joint-action quantal data in quantitative risk assessment
- Benchmark dose profiles for joint-action continuous data in quantitative risk assessment
- Bayesian Model Averaging With Applications to Benchmark Dose Estimation for Arsenic in Drinking Water
- Benchmark dose calculation from epidemiological data
- scientific article; zbMATH DE number 5668406 (Why is no real title available?)
- Benchmark dose risk analysis with mixed-factor quantal data in environmental risk assessment
- Estimation of the benchmark dose for right-censored lifetime data
- Estimation of the benchmark dose by structural equation models
- Nonparametric benchmark dose estimation with continuous dose-response data
- BMA‐Mod: A Bayesian model averaging strategy for determining dose‐response relationships in the presence of model uncertainty
- Benchmark profile and inferences for joint-exposure quantal data in quantitative risk assessment
This page was built for publication: Bayesian model-averaged benchmark dose analysis via reparameterized quantal-response models
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2809552)
