Bayesian model-averaged benchmark dose analysis via reparameterized quantal-response models

DOI10.1111/BIOM.12340zbMATH Open1395.62337arXiv1402.3896OpenAlexW2164822863WikidataQ40808409 ScholiaQ40808409MaRDI QIDQ2809552FDOQ2809552

Authors: Q. Fang, Susan J. Simmons, X. Li, C. Chen, Y. Wang, W. W. Piegorsch 

Publication date: 30 May 2016

Published in: Biometrics (Search for Journal in Brave)

Abstract: An important objective in biomedical risk assessment is estimation of minimum exposure levels that induce a pre-specified adverse response in a target population. The exposure/dose points in such settings are known as Benchmark Doses (BMDs). Recently, parametric Bayesian estimation for finding BMDs has become popular. A large variety of candidate dose-response models is available for applying these methods, however, leading to questions of model adequacy and uncertainty. Here we enhance the Bayesian estimation technique for BMD analysis by applying Bayesian model averaging to produce point estimates and (lower) credible bounds. We include reparameterizations of traditional dose-response models that allow for more-focused use of elicited prior information when building the Bayesian hierarchy. Performance of the method is evaluated via a short simulation study. An example from carcinogenicity testing illustrates the calculations.

Full work available at URL: https://arxiv.org/abs/1402.3896

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zbMATH Keywords

model uncertaintyhierarchical modelingquantitative risk assessmentbenchmark analysismultimodel inferencedose-response analysisBayesian BMDL

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

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Cited In (7)

• Benchmark dose profiles for joint-action quantal data in quantitative risk assessment
• Bayesian Model Averaging With Applications to Benchmark Dose Estimation for Arsenic in Drinking Water
• Benchmark dose calculation from epidemiological data
• Title not available (Why is that?)
• Benchmark dose risk analysis with mixed-factor quantal data in environmental risk assessment
• Estimation of the benchmark dose by structural equation models
• BMA‐Mod: A Bayesian model averaging strategy for determining dose‐response relationships in the presence of model uncertainty

Uses Software

• R
• tsbridge
• BMDS

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