Margination of white blood cells: a computational approach by a hydrodynamic phase field model
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Publication:2812082
DOI10.1017/JFM.2016.15zbMATH Open1382.76304arXiv1507.01544OpenAlexW3103516681MaRDI QIDQ2812082FDOQ2812082
Authors: Wieland Marth, Sebastian Aland, Axel Voigt 
Publication date: 16 June 2016
Published in: Journal of Fluid Mechanics (Search for Journal in Brave)
Abstract: We numerically investigate margination of white blood cells and demonstrate the dependency on a number of conditions including hematocrit, the deformability of the cells and the Reynolds number. A detailed mesoscopic hydrodynamic Helfrich-type model is derived, validated and used for the simulations to provides a quantitative description of the margination of white blood cells. Previous simulation results, obtained with less detailed models, could be confirmed, e.g. the largest probability of margination of white blood cells at an intermediate range of hematocrit values and a decreasing tendency with increasing deformability. The consideration of inertia effects, which become of relevance in small vessels, also shows a dependency and leads to less pronounced margination of white blood cells with increasing Reynolds number.
Full work available at URL: https://arxiv.org/abs/1507.01544
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Cites Work
- Software concepts and numerical algorithms for a scalable adaptive parallel finite element method
- Dynamics of multicomponent vesicles in a viscous fluid
- Simulating the dynamics of inextensible vesicles by the penalty immersed boundary method
- Analysis of a phase field Navier-Stokes vesicle-fluid interaction model
- Adaptive full domain covering meshes for parallel finite element computations
- Simulating the deformation of vesicle membranes under elastic bending energy in three dimensions
- An adaptive finite element multi-mesh approach for interacting deformable objects in flow
- A phase field formulation of the Willmore problem
- Diffuse interface models of locally inextensible vesicles in a viscous fluid
- A level set projection model of lipid vesicles in general flows
- Inertial migration of rigid spheres in two-dimensional unidirectional flows
- A phase field model for vesicle-substrate adhesion
- Reynolds number effects on lipid vesicles
- Dynamics of Biomembranes: Effect of the Bulk Fluid
- A boundary integral method for simulating the dynamics of inextensible vesicles suspended in a viscous fluid in 2D
- The dynamics of a vesicle in simple shear flow
- Simulating vesicle-substrate adhesion using two phase field functions
- Rheology of a dilute two-dimensional suspension of vesicles
- Inertial migration of rigid spherical particles in Poiseuille flow
- Thermodynamically consistent models for two-component vesicles
- The motion of rigid particles in a shear flow at low Reynolds number
- Inertial migration of a sphere in Poiseuille flow
- Signaling networks and cell motility: a computational approach using a phase field description
- The inertial lift on a spherical particle in a plane Poiseuille flow at large channel Reynolds number
- Leukocyte margination in a model microvessel
Cited In (17)
- Phase field models for two-phase flow with surfactants and biomembranes
- Interplay of deformability and adhesion on localization of elastic micro-particles in blood flow
- Defects in active nematics - algorithms for identification and tracking
- An efficient and robust Lagrange multiplier approach with a penalty term for phase-field models
- Migration and deformation of leukocytes in pressure-driven flows
- An adaptive finite element multi-mesh approach for interacting deformable objects in flow
- Diffuse interface model for cell interaction and aggregation with lennard-Jones type potential
- An Energy Stable $C^0$ Finite Element Scheme for A Phase-Field Model of Vesicle Motion and Deformation
- Step-by-step solving schemes based on scalar auxiliary variable and invariant energy quadratization approaches for gradient flows
- A numerical method for the simulation of viscoelastic fluid surfaces
- Phase-field Navier-Stokes model for vesicle doublets hydrodynamics in incompressible fluid flow
- The Exponential Scalar Auxiliary Variable (E-SAV) Approach for Phase Field Models and Its Explicit Computing
- A highly efficient and accurate exponential semi-implicit scalar auxiliary variable (ESI-SAV) approach for dissipative system
- Efficient fully discrete spectral-Galerkin scheme for the volume-conserved multi-vesicular phase-field model of lipid vesicles with adhesion potential
- The stabilized-trigonometric scalar auxiliary variable approach for gradient flows and its efficient schemes
- Fully-discrete Spectral-Galerkin scheme with second-order time-accuracy and unconditionally energy stability for the volume-conserved phase-field lipid vesicle model
- Efficient linear, fully-decoupled and energy stable numerical scheme for a variable density and viscosity, volume-conserved, hydrodynamically coupled phase-field elastic bending energy model of lipid vesicles
Uses Software
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