A model of morphogen transport in the presence of glypicans. III.

DOI10.1016/J.NONRWA.2016.01.007zbMATH Open1342.35413arXiv1411.7722OpenAlexW2767478865MaRDI QIDQ282003FDOQ282003

Authors: Marcin Małogrosz 

Publication date: 11 May 2016

Published in: Nonlinear Analysis. Real World Applications (Search for Journal in Brave)

Abstract: We analyse a stationary problem for the two dimensional model of morphogen transport introduced by Hufnagel et al. The model consists of one linear elliptic PDE posed on $(-1,1)imes(0,h)$ which is coupled via a nonlinear boundary condition with a nonlinear elliptic PDE posed on $(-1,1)imes0$. The main result is that the system has a unique steady state for all ranges of parameters present in the system. Moreover we consider the problem of the dimension reduction. After introducing an appropriate scaling in the model we prove that, as $ho0$, the stationary solution converges to the unique steady state of the one dimensional simplification of the model which was analysed in the first part of the paper. The main difficulty in obtaining appropriate estimates stems from the presence of a measure source term in the boundary condition.

Full work available at URL: https://arxiv.org/abs/1411.7722

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zbMATH Keywords

dimension reductionuniquenessmorphogen transportsingular boundary conditionstationary problemsystem of elliptic PDEs

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

Cites Work

• Nonlinear elliptic and parabolic equations involving measure data
• Mathematical analysis of a model of morphogenesis
• Semi-linear second-order elliptic equations in \(L^1\)
• A model of morphogen transport in the presence of glypicans. I
• Mathematical models of receptor-mediated transport of morphogens
• Mathematical analysis of a model of chemotaxis arising from morphogenesis
• Well-Posedness and Convergence to the Steady State for a Model of Morphogen Transport
• Regularity of solutions of an elliptic boundary value problem i n a rectangle
• A model of morphogen transport in the presence of glypicans. II
• Well-posedness and asymptotic behavior a multidimensional model of morphogen transport

Cited In (4)

• A model of morphogen transport in the presence of glypicans. II
• A model of morphogen transport in the presence of glypicans. I
• Turing type instability in a diffusion model with mass transport on the boundary
• Well-Posedness and Convergence to the Steady State for a Model of Morphogen Transport

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