Efficient design for clinically relevant intent-to-treat comparisons

zbMATH Open1397.92321MaRDI QIDQ2829293FDOQ2829293

Authors: Ree Dawson, Philip W. Lavori 

Publication date: 27 October 2016

Recommendations

• Sequential multiple assignment randomization trials with enrichment design
• Design and analysis considerations for comparing dynamic treatment regimens with binary outcomes from sequential multiple assignment randomized trials
• SMART design, conduct, and analysis in oncology
• Comparison of designs for adaptive treatment strategies: Baseline vs. adaptive randomization
• Imputing missing data from sequential multiple assignment randomized trials

zbMATH Keywords

dynamic treatment regimesequential multiple assignment randomized trialintention to treat principle

Mathematics Subject Classification ID

Medical applications (general) (92C50) Statistical block designs (62K10) General biostatistics (92B15)

Cited In (6)

• Sequential multiple assignment randomization trials with enrichment design
• Sample size calculations for clustered SMART designs
• SMART design, conduct, and analysis in oncology
• Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment
• Efficient design and inference for multistage randomized trials of individualized treatment policies
• Design and analysis considerations for comparing dynamic treatment regimens with binary outcomes from sequential multiple assignment randomized trials

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