Clinical trials for personalized dose finding

zbMATH Open1417.92068MaRDI QIDQ2829305FDOQ2829305

Authors: Guanhua Chen, Donglin Zeng 

Publication date: 27 October 2016

Recommendations

• Patient-specific dose finding in phase I clinical trials
• The treatment versus experimentation dilemma in dose finding studies
• Individualized dosing for multiple ordered groups of patients
• Pharmacokinetically guided optimum adaptive dose selection in early phase clinical trials
• Patient‐Specific Dose Finding Based on Bivariate Outcomes and Covariates

zbMATH Keywords

clinical trialsoptimal treatment dose identification

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Cited In (5)

• Individualized dosing for multiple ordered groups of patients
• A utility approach to individualized optimal dose selection using biomarkers
• Overcoming inefficiencies in the development of personalized medicine
• Personalized medicine -- optimized EPO dosing
• Patient‐Specific Dose Finding Based on Bivariate Outcomes and Covariates

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