Predicting single-neuron activity in locally connected networks

DOI10.1162/NECO_A_00343zbMATH Open1268.92018arXiv1506.04301WikidataQ39191401 ScholiaQ39191401MaRDI QIDQ2840862FDOQ2840862

Feraz Azhar, William S. Anderson

Publication date: 23 July 2013

Published in: Neural Computation (Search for Journal in Brave)

Abstract: The characterization of coordinated activity in neuronal populations has received renewed interest in the light of advancing experimental techniques which allow recordings from multiple units simultaneously. Across both in vitro and in vivo preparations, nearby neurons show coordinated responses when spontaneously active, and when subject to external stimuli. Recent work (Truccolo, Hochberg, & Donoghue, 2010) has connected these coordinated responses to behavior, showing that small ensembles of neurons in arm related areas of sensorimotor cortex can reliably predict single-neuron spikes in behaving monkeys and humans. We investigate this phenomenon utilizing an analogous point process model, showing that in the case of a computational model of cortex responding to random background inputs, one is similarly able to predict the future state of a single neuron by considering its own spiking history, together with the spiking histories of randomly sampled ensembles of nearby neurons. This model exhibits realistic cortical architecture and displays bursting episodes in the two distinct connectivity schemes studied. We conjecture that the baseline predictability we find in these instances is characteristic of locally connected networks more broadly considered.

Full work available at URL: https://arxiv.org/abs/1506.04301

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Mathematics Subject Classification ID

Point processes (e.g., Poisson, Cox, Hawkes processes) (60G55) Neural biology (92C20) Neural networks for/in biological studies, artificial life and related topics (92B20) Computational methods for problems pertaining to biology (92-08)

Cites Work

• An Introduction to the Theory of Point Processes
• Maximum likelihood identification of neural point process systems
• Maximum likelihood analysis of spike trains of interacting nerve cells
• Analyzing Functional Connectivity Using a Network Likelihood Model of Ensemble Neural Spiking Activity
• A mathematical framework for inferring connectivity in probabilistic neuronal networks
• Changing excitation and inhibition in simulated neural networks: effects on induced bursting behavior
• The role of a transient potassium current in a bursting neuron model
• Studies of stimulus parameters for seizure disruption using neural network simulations
• Nonconvergence in Logistic and Poisson Models for Neural Spiking

Cited In (1)

• Dynamic branching in a neural network model for probabilistic prediction of sequences

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