Predicting single-neuron activity in locally connected networks

DOI10.1162/NECO_A_00343MaRDI QIDQ2840862zbMATH OpenWikidataFDO

Authors Feraz Azhar, William S. Anderson

Publication date 23 July 2013

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1506.04301

Mathematics Subject Classification ID

Point processes (e.g., Poisson, Cox, Hawkes processes) (60G55) Neural biology (92C20) Neural networks for/in biological studies, artificial life and related topics (92B20) Computational methods for problems pertaining to biology (92-08)

Abstract: The characterization of coordinated activity in neuronal populations has received renewed interest in the light of advancing experimental techniques which allow recordings from multiple units simultaneously. Across both in vitro and in vivo preparations, nearby neurons show coordinated responses when spontaneously active, and when subject to external stimuli. Recent work (Truccolo, Hochberg, & Donoghue, 2010) has connected these coordinated responses to behavior, showing that small ensembles of neurons in arm related areas of sensorimotor cortex can reliably predict single-neuron spikes in behaving monkeys and humans. We investigate this phenomenon utilizing an analogous point process model, showing that in the case of a computational model of cortex responding to random background inputs, one is similarly able to predict the future state of a single neuron by considering its own spiking history, together with the spiking histories of randomly sampled ensembles of nearby neurons. This model exhibits realistic cortical architecture and displays bursting episodes in the two distinct connectivity schemes studied. We conjecture that the baseline predictability we find in these instances is characteristic of locally connected networks more broadly considered.

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Cites work

• A mathematical framework for inferring connectivity in probabilistic neuronal networks
• An Introduction to the Theory of Point Processes
• Analyzing Functional Connectivity Using a Network Likelihood Model of Ensemble Neural Spiking Activity
• Changing excitation and inhibition in simulated neural networks: effects on induced bursting behavior
• Maximum likelihood analysis of spike trains of interacting nerve cells
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• Studies of stimulus parameters for seizure disruption using neural network simulations
• The role of a transient potassium current in a bursting neuron model

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(3)

• Spike signal transmission between modules and the predictability of spike activity in modular neuronal networks
• Inferring the location of neurons within an artificial network from their activity
• Dynamic branching in a neural network model for probabilistic prediction of sequences

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