The effects of a telomere destabilizing agent on cancer cell-cycle dynamics -- integrated modelling and experiments

DOI10.1016/J.JTBI.2011.10.038MaRDI QIDQ285141zbMATH OpenOpenAlexWikidataFDO

Authors Bartholomäus V. Hirt, Simon Preston, Charles A. Laughton, Jonathan A. D. Wattis

Publication date 19 May 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2011.10.038

zbMATH Keywords

cell deathmathematical modelmodel identifiabilityparameter estimationRHPS4

Mathematics Subject Classification ID

Cell biology (92C37) Medical applications (general) (92C50)

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Cites work

• A generalised age- and phase-structured model of human tumour cell populations both unperturbed and exposed to a range of cancer therapies
• A mathematical model of cycle-specific chemotherapy
• A new look at the statistical model identification
• Asymptotic results for goodness-of-fit statistics with unknown parameters
• Erratum: ``Modelling the flow of cytometric data obtained from unperturbed human tumour cell lines: parameter fitting and comparison
• scientific article; zbMATH DE number 46726 (Why is no real title available?)
• scientific article; zbMATH DE number 1156422 (Why is no real title available?)
• scientific article; zbMATH DE number 194949 (Why is no real title available?)
• Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies
• Linking cell division to cell growth in a spatiotemporal model of the cell cycle
• Model Selection for Multivariate Regression in Small Samples
• On estimation and hypothesis testing problems for correlation coefficients
• On the identifiability and distinguishability of nonlinear parametric models

Cited in

(2)

• Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs
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