Structure of cell networks critically determines oscillation regularity

DOI10.1016/J.JTBI.2011.12.007zbMATH Open1336.92008arXiv1108.4790OpenAlexW2147758438WikidataQ48765345 ScholiaQ48765345MaRDI QIDQ285207FDOQ285207

Authors: Hiroshi Kori, Yoji Kawamura, Naoki Masuda 

Publication date: 19 May 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Biological rhythms are generated by pacemaker organs, such as the heart pacemaker organ (the sinoatrial node) and the master clock of the circadian rhythms (the suprachiasmatic nucleus), which are composed of a network of autonomously oscillatory cells. Such biological rhythms have notable periodicity despite the internal and external noise present in each cell. Previous experimental studies indicate that the regularity of oscillatory dynamics is enhanced when noisy oscillators interact and become synchronized. This effect, called the collective enhancement of temporal precision, has been studied theoretically using particular assumptions. In this study, we propose a general theoretical framework that enables us to understand the dependence of temporal precision on network parameters including size, connectivity, and coupling intensity; this effect has been poorly understood to date. Our framework is based on a phase oscillator model that is applicable to general oscillator networks with any coupling mechanism if coupling and noise are sufficiently weak. In particular, we can manage general directed and weighted networks. We quantify the precision of the activity of a single cell and the mean activity of an arbitrary subset of cells. We find that, in general undirected networks, the standard deviation of cycle-to-cycle periods scales with the system size $N$ as $1/sqrtN$, but only up to a certain system size $N^{*}$ that depends on network parameters. Enhancement of temporal precision is ineffective when $N>N^{*}$. We also reveal the advantage of long-range interactions among cells to temporal precision.

Full work available at URL: https://arxiv.org/abs/1108.4790

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zbMATH Keywords

noisenetworksynchronizationcircadian rhythmheart

Mathematics Subject Classification ID

Biological rhythms and synchronization (92B25) Cell biology (92C37)

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Cited In (10)

• Title not available (Why is that?)
• Time and Energy Costs for Synchronization of Kuramoto-Oscillator Networks With or Without Noise Perturbation
• Enhanced precision of circadian rhythm by output system
• Integrate and fire model with refractory period for synchronization of two cardiomyocytes
• Synchronization and fluctuation of cardiac muscle cells
• Noise stability of synchronization and optimal network structures
• Collective phase dynamics of globally coupled oscillators: noise-induced anti-phase synchronization
• Generation of slow phase-locked oscillation and variability of the interspike intervals in globally coupled neuronal oscillators
• Six decades of the FitzHugh-Nagumo model: a guide through its spatio-temporal dynamics and influence across disciplines
• The Kuramoto model in complex networks

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