Detecting sparse cone alternatives for Gaussian random fields, with an application to fMRI

DOI10.5705/SS.2012.218SzbMATH Open1417.62119arXiv1207.3840OpenAlexW2962956183MaRDI QIDQ2864547FDOQ2864547

Authors: Jonathan Taylor, Keith J. Worsley 

Publication date: 25 November 2013

Published in: Statistica Sinica (Search for Journal in Brave)

Abstract: Our problem is to find a good approximation to the P-value of the maximum of a random field of test statistics for a cone alternative at each point in a sample of Gaussian random fields. These test statistics have been proposed in the neuroscience literature for the analysis of fMRI data allowing for unknown delay in the hemodynamic response. However the null distribution of the maximum of this 3D random field of test statistics, and hence the threshold used to detect brain activation, was unsolved. To find a solution, we approximate the P-value by the expected Euler characteristic (EC) of the excursion set of the test statistic random field. Our main result is the required EC density, derived using the Gaussian Kinematic Formula.

Full work available at URL: https://arxiv.org/abs/1207.3840

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zbMATH Keywords

random fieldsorder-restricted inferenceEuler characteristicnon-negative least squareskinematic formulaemultivariate one-sided hypothesesvolumes of tubes expansion

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Gaussian processes (60G15) Random fields (60G60) Statistics of extreme values; tail inference (62G32)

Cited In (9)

• Detecting Sparse Signals in Random Fields, With an Application to Brain Mapping
• On the probability density function of the test statistic for one nonlinear GLR detector arising from fMRI
• Rotation space random fields with an application to fMRI data
• An approximation to cluster size distribution of two Gaussian random fields conjunction with application to fMRI data
• Random fields of multivariate test statistics, with applications to shape analysis
• Computation of the expected Euler characteristic for the largest eigenvalue of a real non-central Wishart matrix
• Testing One Hypothesis Multiple Times: The Multidimensional Case
• The volume-of-tube method for Gaussian random fields with inhomogeneous variance
• Detecting activation in fMRI data

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