Sequential analysis of the Cox model under response dependent allocation

DOI10.5705/SS.2012.147SzbMATH Open1417.62231arXiv1106.2790OpenAlexW1558705369WikidataQ38423295 ScholiaQ38423295MaRDI QIDQ2864555FDOQ2864555

Authors: Xiaolong Luo, Gongjun Xu, Zhiliang Ying 

Publication date: 25 November 2013

Published in: Statistica Sinica (Search for Journal in Brave)

Abstract: Sellke and Siegmund (1983) developed the Brownian approximation to the Cox partial likelihood score as a process of calendar time, laying the foundation for group sequential analysis of survival studies. We extend their results to cover situations in which treatment allocations may depend on observed outcomes. The new development makes use of the entry time and calendar time along with the corresponding $sigma$-filtrations to handle the natural information accumulation. Large sample properties are established under suitable regularity conditions.

Full work available at URL: https://arxiv.org/abs/1106.2790

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zbMATH Keywords

clinical trialssurvival analysisstaggered entryweak convergencegroup sequential methodsproportional hazards regressionBrownian approximationoutcome dependent allocation

Mathematics Subject Classification ID

Asymptotic properties of nonparametric inference (62G20) Sequential statistical analysis (62L10)

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