Sequential analysis of the Cox model under response dependent allocation

DOI10.5705/SS.2012.147SMaRDI QIDQ2864555zbMATH OpenOpenAlexWikidataFDO

Authors Xiaolong Luo, Gongjun Xu, Zhiliang Ying

Publication date 25 November 2013

Published in Statistica Sinica (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1106.2790

zbMATH Keywords

clinical trialssurvival analysisstaggered entryweak convergencegroup sequential methodsproportional hazards regressionBrownian approximationoutcome dependent allocation

Mathematics Subject Classification ID

Asymptotic properties of nonparametric inference (62G20) Sequential statistical analysis (62L10)

Abstract: Sellke and Siegmund (1983) developed the Brownian approximation to the Cox partial likelihood score as a process of calendar time, laying the foundation for group sequential analysis of survival studies. We extend their results to cover situations in which treatment allocations may depend on observed outcomes. The new development makes use of the entry time and calendar time along with the corresponding $sigma$-filtrations to handle the natural information accumulation. Large sample properties are established under suitable regularity conditions.

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