Abstract: We consider the optimal design problem for a comparison of two regression curves, which is used to establish the similarity between the dose response relationships of two groups. An optimal pair of designs minimizes the width of the confidence band for the difference between the two regression functions. Optimal design theory (equivalence theorems, efficiency bounds) is developed for this non standard design problem and for some commonly used dose response models optimal designs are found explicitly. The results are illustrated in several examples modeling dose response relationships. It is demonstrated that the optimal pair of designs for the comparison of the regression curves is not the pair of the optimal designs for the individual models. In particular it is shown that the use of the optimal designs proposed in this paper instead of commonly used "non-optimal" designs yields a reduction of the width of the confidence band by more than 50%.
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Cited in
(11)- Optimal designs for dose response curves with common parameters
- Locally optimal designs for comparing curves in generalized linear models
- Optimal designs for comparing population curves in hierarchical models
- On the choice of optimality criteria in comparing statistical designs
- Optimal designs for criteria involving log(potency) in comparative binary bioassays
- Optimal experimental design that minimizes the width of simultaneous confidence bands
- Optimal designs for comparing regression models with correlated observations
- Optimal designs for comparing regression curves: dependence within and between groups
- Identifying Alert Concentrations Using a Model-Based Bootstrap Approach
- Optimal designs for treatment comparisons represented by graphs
- Optimal designs for comparing curves in regression models with asymmetric errors
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