Models and Optimal Control in Freezing and Thawing of Living Cells and Tissues

DOI10.1007/978-3-319-05083-6_10MaRDI QIDQ2945484zbMATHOpenAlexFDO

Authors Karl-Heinz Hoffmann, Nikolai D. Botkin, Varvara L. Turova

Publication date 11 September 2015

Published in International Series of Numerical Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/978-3-319-05083-6_10

zbMATH Keywords

Hamilton-Jacobi equationsmathematical modelcontrol systemgrid methodsdamaging factorsfreezing and thawing of biological cellsoptimal cooling and warming rates

Mathematics Subject Classification ID

Hamilton-Jacobi equations (35F21) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Existence theories for optimal control problems involving partial differential equations (49J20) Dynamic programming in optimal control and differential games (49L20) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) General biology and biomathematics (92B05)

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Cited in

(10)

• Entropy generation at the cellular level during freezing process of biological materials
• The front-tracking ALE method: application to a model of the freezing of cell suspensions
• Fundamentals of cryobiology. Physical phenomena and mathematical models
• Heat transfer analysis for the design and application of the passive cooling rate controlled device-box-in-box
• Freezing of living cells: mathematical models and design of optimal cooling protocols
• Analytical optimal controls for the state constrained addition and removal of cryoprotective agents
• Optimal control in cryopreservation of cells and tissues
• A mathematical framework for developing freezing protocols in the cryopreservation of cells
• Simulation of micro-scale interaction between ice and biological cells.
• Optimal control of ice formation in living cells during freezing

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