First passage time statistics for two-channel diffusion

DOI10.1088/1751-8121/AA5204MaRDI QIDQ2969879zbMATH OpenOpenAlexFDO

Authors Aljaž Godec, Ralf Metzler

Publication date 23 March 2017

Published in Journal of Physics A: Mathematical and Theoretical (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1608.02397

zbMATH Keywords

asymptotic analysisfirst passage timeFokker-Planck equationMarkov additive processescellular signallingcoupled intial boundary value problemrandom search processes

Mathematics Subject Classification ID

Diffusion processes (60J60) Fokker-Planck equations (35Q84) Laplace transform (44A10) Stochastic methods (Fokker-Planck, Langevin, etc.) applied to problems in time-dependent statistical mechanics (82C31) Statistical mechanics of polymers (82D60) Interface problems; diffusion-limited aggregation in time-dependent statistical mechanics (82C24) Dynamics of random walks, random surfaces, lattice animals, etc. in time-dependent statistical mechanics (82C41) Dynamics of disordered systems (random Ising systems, etc.) in time-dependent statistical mechanics (82C44)

Abstract: We present rigorous results for the mean first passage time and first passage time statistics for two-channel Markov additive diffusion in a 3-dimensional spherical domain. Inspired by biophysical examples we assume that the particle can only recognise the target in one of the modes, which is shown to effect a non-trivial first passage behaviour. We also address the scenario of intermittent immobilisation. In both cases we prove that despite the perfectly non-recurrent motion of two-channel Markov additive diffusion in 3 dimensions the first passage statistics at long times do not display Poisson-like behaviour if none of the phases has a vanishing diffusion coefficient. This stands in stark contrast to the standard (one-channel) Markov diffusion counterpart. We also discuss the relevance of our results in the context of cellular signalling.

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Cited in

(22)

• Preface: new trends in first-passage methods and applications in the life sciences and engineering
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• Network navigation with non-Lèvy superdiffusive random walks
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• Fractional compound Poisson processes with multiple internal states
• The effects of fast inactivation on conditional first passage times of mortal diffusive searchers

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