Screening tests for disease risk haplotype segments in genome by use of permutation

MaRDI QIDQ2993350zbMATH OpenFDO

Authors Fadhaa Ali, Jian Zhang

Publication date 10 August 2016

zbMATH Keywords

expectation-maximization algorithmgenome wide association studiesodds ratiosgenotype mixture modelsregion-based association analysis

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited in

(4)

• Search for risk haplotype segments with GWAS data by use of finite mixture models
• An exact test for the association between the disease and alleles at highly polymorphic loci with particular interest in the haplotype analysis
• Powerful testing via hierarchical linkage disequilibrium in haplotype association studies
• Mixture model-based association analysis with case-control data in genome wide association studies

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