A hierarchical extension scheme for solutions of the Wright-Fisher model

DOI10.4310/CMS.2016.V14.N4.A11MaRDI QIDQ305082zbMATH OpenOpenAlexFDO

Authors Julian Hofrichter, Tat Dat Tran, Jürgen Jost

Publication date 26 August 2016

Published in Communications in Mathematical Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1406.5152

zbMATH Keywords

Wright-Fisher modelforward Kolmogorov equationhierarchical solutionrandom genetic drift

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Degenerate parabolic equations (35K65)

Abstract: We develop a global and hierarchical scheme for the forward Kolmogorov (Fokker-Planck) equation of the diffusion approximation of the Wright-Fisher model of population genetics. That model describes the random genetic drift of several alleles at the same locus in a population. The key of our scheme is to connect the solutions before and after the loss of an allele. Whereas in an approach via stochastic processes or partial differential equations, such a loss of an allele leads to a boundary singularity, from a biological or geometric perspective, this is a natural process that can be analyzed in detail. Our method depends on evolution equations for the moments of the process and a careful analysis of the boundary flux.

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Cited in

(8)

• A general solution of the Wright-Fisher model of random genetic drift
• The uniqueness of hierarchically extended backward solutions of the Wright-Fisher model
• Boundary estimates for a degenerate parabolic equation with partial Dirichlet boundary conditions
• Eigenfunctions and the Dirichlet Problem for the Classical Kimura Diffusion Operator
• Genealogy of a Wright-Fisher Model with Strong SeedBank Component
• The evolution of moment generating functions for the Wright-Fisher model of population genetics
• A boundary preserving numerical algorithm for the Wright-Fisher model with mutation
• Transition probabilities for degenerate diffusions arising in population genetics

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