Inference for quantitation parameters in polymerase chain reactions via branching processes with random effects

DOI10.1198/JASA.2011.TM08601MaRDI QIDQ3095172zbMATH OpenOpenAlexFDO

Authors Bret Hanlon, Anand N. Vidyashankar

Publication date 28 October 2011

Published in Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1198/jasa.2011.tm08601

zbMATH Keywords

generalized method of momentsmartingale limitsbetween-reaction variabilitywithin-reaction variability

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40) Applications of branching processes (60J85) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cited in

(14)

• Reducing bias and quantifying uncertainty in fluorescence produced by PCR
• A minimally parametrized branching process explaining plateau phase of qPCR amplification
• Estimating the accuracy of polymerase chain reaction-based tests using endpoint dilution
• Evaluation of different statistical methods using SAS software: an in silico approach for analysis of real-time PCR data
• A test of homogeneity for age-dependent branching processes with immigration
• Estimating marginal properties of quantitative real-time PCR data using nonlinear mixed models
• A Bayesian hierarchical model for quantitative real-time PCR data
• What can be observed in real time PCR and when does it show?
• Ancestral inference for branching processes in random environments and an application to polymerase chain reaction
• Statistical models in assessing fold change of gene expression in real-time RT-PCR experiments
• A quantitative approach for polymerase chain reactions based on a hidden Markov model
• Modelling the PCR amplification process by a size-dependent branching process and estimation of the efficiency
• Bayesian Estimation for Quantification by Real-time Polymerase Chain Reaction Under a Branching Process Model of the DNA Molecules Amplification Process
• Statistical Inference for Quantitative Polymerase Chain Reaction Using a Hidden Markov Model: A Bayesian Approach

Describes a project that uses

Uses Software

• qpcR

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