Averaging for a Fully Coupled Piecewise-Deterministic Markov Process in Infinite Dimensions

DOI10.1239/AAP/1346955263zbMATH Open1276.60023OpenAlexW2962966813MaRDI QIDQ3167337FDOQ3167337

Authors Alexandre Genadot, Michèle Thieullen 

Publication date 2 November 2012

Published in Advances in Applied Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1109.6581

zbMATH Keywords

slow-fast systemaveraging principleHodgkin-Huxley modelpiecewise-deterministic Markov processneuron modelstochastic hybrid system

Mathematics Subject Classification ID

Central limit and other weak theorems (60F05) Neural biology (92C20) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Random linear operators (47B80)

Abstract: In this paper, we consider the generalized Hodgkin-Huxley model introduced by Austin in cite{Austin}. This model describes the propagation of an action potential along the axon of a neuron at the scale of ion channels. Mathematically, this model is a fully-coupled Piecewise Deterministic Markov Process (PDMP) in infinite dimension. We introduce two time scales in this model in considering that some ion channels open and close at faster jump rates than others. We perform a slow-fast analysis of this model and prove that asymptotically this two time scales model reduces to the so called averaged model which is still a PDMP in infinite dimension for which we provide effective evolution equations and jump rates.

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• An exact stochastic hybrid model of excitable membranes including spatio-temporal evolution
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• Singular perturbation for the discounted continuous control of piecewise deterministic Markov processes
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Cited In (12)

• Stationary Averaging for Multiscale Continuous Time Markov Chains Using Parallel Replica Dynamics
• Semi-parametric inference for the absorption features of a growth-fragmentation model
• Emergence of oscillatory behaviors for excitable systems with noise and mean-field interaction: a slow-fast dynamics approach
• Multiscale Piecewise Deterministic Markov Process in infinite dimension: central limit theorem and Langevin approximation
• Spatio-temporal averaging for a class of hybrid systems and application to conductance-based neuron models
• Optimal control of infinite-dimensional piecewise deterministic Markov processes and application to the control of neuronal dynamics via optogenetics
• A spatial measure-valued model for chemical reaction networks in heterogeneous systems
• Stability in distribution of path-dependent hybrid diffusion
• Exponential ergodicity for Markov processes with random switching
• Piecewise deterministic Markov process -- recent results
• Averaging and large deviation principles for fully-coupled piecewise deterministic Markov processes and applications to molecular motors
• Spatio-temporal hybrid (PDMP) models: central limit theorem and Langevin approximation for global fluctuations. Application to electrophysiology

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