Analytical study of an exclusive genetic switch
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Publication:3173016
Biochemistry, molecular biology (92C40) Genetics and epigenetics (92D10) Dynamical systems in biology (37N25) Probabilistic models, generic numerical methods in probability and statistics (65C20) Systems biology, networks (92C42) PDEs in connection with biology, chemistry and other natural sciences (35Q92)
Abstract: The nonequilibrium stationary state of an exclusive genetic switch is considered. The model comprises two competing species and a single binding site which, when bound to by a protein of one species, causes the other species to be repressed. The model may be thought of as a minimal model of the power struggle between two competing parties. Exact solutions are given for the limits of vanishing binding/unbinding rates and infinite binding/unbinding rates. A mean field theory is introduced which is exact in the limit of vanishing binding/unbinding rates. The mean field theory and numerical simulations reveal that generically bistability occurs and the system is in a symmetry broken state. An exact perturbative solution which in principle allows the nonequilibrium stationary state to be computed is also developed and computed to first and second order.
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