Adaptive Randomization for Multiarm Comparative Clinical Trials Based on Joint Efficacy/Toxicity Outcomes

DOI10.1111/J.1541-0420.2008.01175.XMaRDI QIDQ3183237zbMATHOpenAlexWikidataFDO

Authors Yuan Ji, B. Nebiyou Bekele

Publication date 19 October 2009

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/j.1541-0420.2008.01175.x

zbMATH Keywords

posterioraugmented likelihoodlatent modelfollow-upassessment time

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Recommendations

• Bayesian phase II adaptive randomization by jointly modeling time-to-event efficacy and binary toxicity
• Efficient adaptive randomization and stopping rules in multi-arm clinical trials for testing a new treatment
• Comparison of designs for adaptive treatment strategies: Baseline vs. adaptive randomization
• Optimal and lead-in adaptive allocation for binary outcomes: a comparison of Bayesian methods
• A randomized play-the-winner design for multi-arm clinical trials

Cites work

• A Continuous Bivariate Exponential Extension
• Adaptive decision making in a lymphocyte infusion trial
• Bivariate Survival Models Induced by Frailties
• Monitoring the rates of composite events with censored data in phase II clinical trials
• Multivariate Generalizations of the Proportional Hazards Model
• Response-Adaptive Randomization for Survival Trials: The Parametric Approach
• Sequential Designs for Phase I Clinical Trials with Late‐Onset Toxicities
• The Calculation of Posterior Distributions by Data Augmentation

Cited in

(1)

• Bayesian phase II adaptive randomization by jointly modeling time-to-event efficacy and binary toxicity

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