Symmetric Group Sequential Test Designs

DOI10.2307/2531692MaRDI QIDQ3201548zbMATH OpenOpenAlexWikidataFDO

Authors Scott S. Emerson, Thomas Fleming

Publication date 1989

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://semanticscholar.org/paper/9650c53ef5172df79b7c2587a0e8a71b5d07c4f2

zbMATH Keywords

stopping boundariessymmetric designsinterim analysesclinicial trial designsGroup sequential test designsPhase III clinical trialssymmetric one-sided group sequential designsunequal group sizes

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

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(19)

• Comparison of numerical algorithms for bivariate sequential tests based on marginal criteria
• Three-stage designs for monitoring clinical trials
• Group sequential designs for one-sided and two-sided hypothesis testing with provision for early stopping in favor of the null hypothesis
• CONDITIONAL PROBABILITY OF SIGNIFICANCE FOR EARLY STOPPING IN FAVOR OFH₀
• GROUP SEQUENTIAL TESTS WITH OUTCOME-DEPENDENT TREATMENT ASSIGNMENT
• Asymmetric group sequential designs under fractional Brownian motion
• Unbalanced and partial group sequential methods for normal responses in clinical trials
• Optimal asymmetric one-sided group sequential tests
• A Unifying Family of Group Sequential Test Designs
• Group sequential designs using both type I and type II error probability spending functions
• Interim evaluation of efficacy or futility in group‐sequential trials with multiple co‐primary endpoints
• On group sequential tests for data in unequally sized groups and with unknown variance
• Principles of Optimal Sequential Planning
• Asymptotically optimal multistage tests for non-i.i.d. data
• Approximately Optimal One-Parameter Boundaries for Group Sequential Trials
• Group sequential designs for clinical trials with bivariate endpoints
• Basic concepts of group sequential and adaptive group sequential test procedures
• Estimation of a secondary parameter in a group sequential clinical trial
• Truncated group sequential test for clinical trials

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