Existence and uniqueness of solutions for a model of non-sarcomeric actomyosin bundles

DOI10.3934/DCDS.2016014zbMATH Open1351.35235arXiv1511.08626OpenAlexW2264417007MaRDI QIDQ321607FDOQ321607

Authors: Christian Schmeiser, Stefanie Hirsch, Dietmar Ölz 

Publication date: 14 October 2016

Published in: Discrete and Continuous Dynamical Systems (Search for Journal in Brave)

Abstract: The model for disordered actomyosin bundles recently derived by Oelz, in the work 'A viscous two-phase model for contractile actomyosin bundles' (Math. Biol., 68 (2013), 1653--1676) includes the effects of cross-linking of parallel and anti-parallel actin filaments, their polymerization and depolymerization, and, most importantly, the interaction with the motor protein myosin, which leads to sliding of anti-parallel filaments relative to each other. The model relies on the assumption that actin filaments are short compared to the length of the bundle. It is a two-phase model which treats actin filaments of both orientations separately. It consists of quasi-stationary force balances determining the local velocities of the filament families and of transport equations for the filaments. Two types of initial-boundary value problems are considered, where either the bundle length or the total force on the bundle are prescribed. In the latter case, the bundle length is determined as a free boundary. Local in time existence and uniqueness results are proven. For the problem with given bundle length, a global solution exists for short enough bundles. For small prescribed force, a formal approximation can be computed explicitly, and the bundle length tends to a limiting value.

Full work available at URL: https://arxiv.org/abs/1511.08626

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zbMATH Keywords

long time behaviorasymptotic methods(free) boundary value problemactomyosin bundlesfixed-point methods

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Overdetermined initial-boundary value problems for PDEs and systems of PDEs (35N30)

Cites Work

• A drift-diffusion model for molecular motor transport in anisotropic filament bundles
• A viscous two-phase model for contractile actomyosin bundles
• Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array
• On the asymptotic regime of a model for friction mediated by transient elastic linkages
• Derivation of a model for symmetric lamellipodia with instantaneous cross-link turnover

Cited In (1)

• Energetics and dynamics of global integrals modeling interaction between stiff filaments

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