Existence and uniqueness of solutions for a model of non-sarcomeric actomyosin bundles

DOI10.3934/DCDS.2016014MaRDI QIDQ321607zbMATH OpenOpenAlexFDO

Authors Christian Schmeiser, Stefanie Hirsch, Dietmar Ölz

Publication date 14 October 2016

Published in Discrete and Continuous Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1511.08626

zbMATH Keywords

long time behaviorasymptotic methods(free) boundary value problemactomyosin bundlesfixed-point methods

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Overdetermined initial-boundary value problems for PDEs and systems of PDEs (35N30)

Abstract: The model for disordered actomyosin bundles recently derived by Oelz, in the work 'A viscous two-phase model for contractile actomyosin bundles' (Math. Biol., 68 (2013), 1653--1676) includes the effects of cross-linking of parallel and anti-parallel actin filaments, their polymerization and depolymerization, and, most importantly, the interaction with the motor protein myosin, which leads to sliding of anti-parallel filaments relative to each other. The model relies on the assumption that actin filaments are short compared to the length of the bundle. It is a two-phase model which treats actin filaments of both orientations separately. It consists of quasi-stationary force balances determining the local velocities of the filament families and of transport equations for the filaments. Two types of initial-boundary value problems are considered, where either the bundle length or the total force on the bundle are prescribed. In the latter case, the bundle length is determined as a free boundary. Local in time existence and uniqueness results are proven. For the problem with given bundle length, a global solution exists for short enough bundles. For small prescribed force, a formal approximation can be computed explicitly, and the bundle length tends to a limiting value.

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Cites work

• A drift-diffusion model for molecular motor transport in anisotropic filament bundles
• A viscous two-phase model for contractile actomyosin bundles
• Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array
• Derivation of a model for symmetric lamellipodia with instantaneous cross-link turnover
• On the asymptotic regime of a model for friction mediated by transient elastic linkages

Cited in

(1)

• Energetics and dynamics of global integrals modeling interaction between stiff filaments

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