Multi-domain sampling with applications to structural inference of Bayesian networks

DOI10.1198/JASA.2011.AP10346MaRDI QIDQ3225797zbMATH OpenOpenAlexFDO

Authors Qing Zhou

Publication date 22 March 2012

Published in Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1110.3392

zbMATH Keywords

Monte CarloWang-Landau algorithmnetwork structuremultimodal distributiondomain-based representationprotein-signaling network

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Monte Carlo methods (65C05)

Abstract: When a posterior distribution has multiple modes, unconditional expectations, such as the posterior mean, may not offer informative summaries of the distribution. Motivated by this problem, we propose to decompose the sample space of a multimodal distribution into domains of attraction of local modes. Domain-based representations are defined to summarize the probability masses of and conditional expectations on domains of attraction, which are much more informative than the mean and other unconditional expectations. A computational method, the multi-domain sampler, is developed to construct domain-based representations for an arbitrary multimodal distribution. The multi-domain sampler is applied to structural learning of protein-signaling networks from high-throughput single-cell data, where a signaling network is modeled as a causal Bayesian network. Not only does our method provide a detailed landscape of the posterior distribution but also improves the accuracy and the predictive power of estimated networks.

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Cited in

(11)

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• Estimation of Gaussian directed acyclic graphs using partial ordering information with applications to DREAM3 networks and dairy cattle data
• Structural factor equation models for causal network construction via directed acyclic mixed graphs
• Inferring large graphs using \(\ell_1\)-penalized likelihood
• Gaussian Bayesian network comparisons with graph ordering unknown

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