Adjoint sensitivity analysis of a tumor growth model and its application to spatiotemporal radiotherapy optimization

DOI10.3934/MBE.2016034zbMATH Open1349.92073OpenAlexW2514873267WikidataQ50561905 ScholiaQ50561905MaRDI QIDQ326540FDOQ326540

Authors Krzysztof Fujarewicz, Krzysztof Łakomiec

Publication date 12 October 2016

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3934/mbe.2016034

zbMATH Keywords

sensitivity analysisdifference equationspartial differential equationstumor growthspatial systems

Mathematics Subject Classification ID

Numerical optimization and variational techniques (65K10) Medical applications (general) (92C50) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06)

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Cites work

• A mathematical model for brain tumor response to radiation therapy
• Artificial Intelligence and Soft Computing - ICAISC 2004
• On fitting of mathematical models of cell signaling pathways using adjoint systems
• Parameter estimation of systems with delays via structural sensitivity analysis
• System Engineering Approach to Planning Anticancer Therapies

Cited in

(2)

• Spatiotemporal sensitivity of systems modeled by cellular automata
• Estimation of initial functions for systems with delays from discrete measurements

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