Mathematical modeling and systems pharmacology of tuberculosis: isoniazid as a case study

DOI10.1016/J.JTBI.2016.03.038MaRDI QIDQ327196zbMATH OpenOpenAlexWikidataFDO

Authors Laure Lalande, Laurent Bourguignon, Pascal Maire, Sylvain Goutelle

Publication date 19 October 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2016.03.038

zbMATH Keywords

immune responsepharmacodynamicspharmacokinetics\textit{Mycobacterium tuberculosis}antimycobacterial drugs

Mathematics Subject Classification ID

Medical epidemiology (92C60) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment
• Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin
• The human immune response to \textit{Mycobacterium tuberculosis} in lung and lymph node

Cited in

(7)

• Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin
• Docking simulations and QM/MM studies between isoniazid prodrug, catalase-peroxidase (KatG) and S315T mutant from mycobacterium tuberculosis
• A model of isoniazid treatment of tuberculosis
• A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment
• YAGYOPATHY VERSUS ORAL AND IV DRUG ADMINISTRATION: EVALUATION FOR PULMONARY TUBERCULOSIS USING COMPARTMENT MODELING
• MATHEMATICAL MODELING OF CHEMOTHERAPY OF HUMAN TB INFECTION
• A pipeline for testing drug mechanism of action and combination therapies: from microarray data to simulations via linear-in-flux-expressions. Testing four-drug combinations for tuberculosis treatment

Describes a project that uses

Uses Software

• GUI-HDMR

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