Mathematical modeling and systems pharmacology of tuberculosis: isoniazid as a case study

DOI10.1016/J.JTBI.2016.03.038zbMATH Open1347.92031OpenAlexW2327834446WikidataQ40722388 ScholiaQ40722388MaRDI QIDQ327196FDOQ327196

Authors: Laure Lalande, Laurent Bourguignon, Pascal Maire, Sylvain Goutelle 

Publication date: 19 October 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2016.03.038

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zbMATH Keywords

immune responsepharmacodynamicspharmacokinetics\textit{Mycobacterium tuberculosis}antimycobacterial drugs

Mathematics Subject Classification ID

Medical epidemiology (92C60) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin
• A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment
• The human immune response to \textit{Mycobacterium tuberculosis} in lung and lymph node

Cited In (7)

• YAGYOPATHY VERSUS ORAL AND IV DRUG ADMINISTRATION: EVALUATION FOR PULMONARY TUBERCULOSIS USING COMPARTMENT MODELING
• MATHEMATICAL MODELING OF CHEMOTHERAPY OF HUMAN TB INFECTION
• A model of isoniazid treatment of tuberculosis
• Docking simulations and QM/MM studies between isoniazid prodrug, catalase-peroxidase (KatG) and S315T mutant from mycobacterium tuberculosis
• Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin
• A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment
• A pipeline for testing drug mechanism of action and combination therapies: from microarray data to simulations via linear-in-flux-expressions. Testing four-drug combinations for tuberculosis treatment

Uses Software

• GUI-HDMR

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