Surface deformation and shear flow in ligand mediated cell adhesion

DOI10.1007/S00285-016-0983-7zbMATH Open1360.92019arXiv1504.05641OpenAlexW2964019225WikidataQ50694761 ScholiaQ50694761MaRDI QIDQ329377FDOQ329377

A. J. Roberts, Sarthok Sircar

Publication date: 21 October 2016

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We present a single, unified, multi-scale model to study the attachmentdetachment dynamics of two deforming, near spherical cells, coated with binding ligands and subject to a slow, homogeneous shear flow in a viscous fluid medium. The binding ligands on the surface of the cells experience attractive and repulsive forces in an ionic medium and exhibit finite resistance to rotation via bond tilting. The macroscale drag forces and couples describing the fluid flow inside the small separation gap between the cells, are calculated using a combination of methods in lubrication theory and previously published numerical results. For a select range of material and fluid parameters, a hysteretic transition of the sticking probability curves between the adhesion and fragmentation domain is attributed to a nonlinear relation between the total microscale binding forces and the separation gap between the cells. We show that adhesion is favored in highly ionic fluids, increased deformability of the cells, elastic binders and a higher fluid shear rate (until a critical value). Continuation of the limit points predict a bistable region, indicating an abrupt switching between the adhesion and fragmentation regimes at critical shear rates, and suggesting that adhesion of two deformable surfaces in shearing fluids may play a significant dynamical role in some cell adhesion applications.

Full work available at URL: https://arxiv.org/abs/1504.05641

zbMATH Keywords

bistabilityadhesionbinding kineticsmicro hydrodynamicssticking probabilitysurface deformation

Mathematics Subject Classification ID

Biomechanics (92C10) Cell biology (92C37)

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Cited In (7)

• Shear induced adhesion: contact mechanics of biological spatula-like attachment devices
• Quantifying macrostructures in viscoelastic sub-diffusive flows
• Title not available (Why is that?)
• On the viscous deformation of biological cells under anisotropic surface tension
• Implicit-explicit-compact methods for advection diffusion reaction equations
• Spatiotemporal linear stability of viscoelastic subdiffusive channel flows: a fractional calculus framework
• Flow past an array of cells that are adherent to the bottom plate of a flow channel

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